| Human menopausal gonadotropin versus highly purified-hMG in controlled ovarian hyperstimulation for in-vitro fertilisation: does purity improve outcome? | |
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MedLine Citation:
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PMID: 20500109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To examine and compare the effect of the two commercially available menotropins (highly purified-human menopausal gonadotropin (HP-hMG) and the traditional human menopausal gonadotropin (hMG)) on ovarian stimulation characteristics and in-vitro fertilisation (IVF) cycle outcome. STUDY DESIGN: We studied 36 patients undergoing at least two controlled ovarian hyperstimulation cycles for IVF, with the same GnRH-analogue protocols, where one included HP-hMG and the other included hMG. Ovarian stimulation characteristics and outcome were compared between the two groups. RESULTS: Patients in the HP-hMG group achieved significantly higher implantation (20.0% vs. 8.1%, p < 0.03; respectively) and pregnancy rates (47.2% vs. 19.4%, p < 0.009; respectively) compared to the hMG group. Although no in-between group difference was observed in the number of top-quality embryos per patient, the proportion of the total number of top-quality embryos per total number of generated embryos was significantly higher in the HP-hMG group (88/196 vs. 72/204, p < 0.049; respectively) as compared to the hMG group. CONCLUSIONS: Patients undergoing controlled ovarian hyperstimulation for IVF that includes HP-hMG preparations produce significantly higher implantation and pregnancy rates, as compared to the traditional hMG. |
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Authors:
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Raoul Orvieto; Simion Meltcer; Gad Liberty; Jacob Rabinson; Eyal Y Anteby; Ravit Nahum |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 733-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, and Ben Gurion University School of Medicine, Beer Sheva, Israel. raoulo@barzi.health.gov.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fertility Agents, Female / therapeutic use* Fertilization in Vitro Humans Infertility, Female / drug therapy* Menotropins / standards, therapeutic use* Ovulation Induction / methods* Pregnancy Pregnancy Rate Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 61489-71-2/Menotropins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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