Document Detail


Human mammary gland function at the onset of lactation: medium-chain fatty acid synthesis.
MedLine Citation:
PMID:  1491609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The onset of medium-chain fatty acid synthesis in the human mammary gland was investigated. Colostrum and serum were collected from 31 healthy women and the fatty acid composition of total lipid was analyzed by gas-liquid chromatography. Although colostrum/serum ratios for most fatty acids range from 0.7-2.4, very low levels of 10:0 and 12:0 were present in serum lipids as compared to much higher concentrations of these fatty acids in colostrum lipids (colostrum/serum ratio 16.23 and 17.11 for 10:0 and 12:0, respectively). We have previously found that medium-chain fatty acid levels are very low in prepartum mammary secretions (6-10 wk before term delivery) but are higher and similar in colostrum of women who deliver preterm (3-14 wk) or at full term. The data indicate that parturition, irrespective of length of pregnancy, is the trigger for medium-chain fatty acid synthesis in the human mammary gland.
Authors:
M L Spear; J Bitman; M Hamosh; D L Wood; D Gavula; P Hamosh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  27     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-03-01     Completed Date:  1993-03-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  908-11     Citation Subset:  IM    
Affiliation:
Division of Neonatology, Medical Center of Delaware, Newark 19718.
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MeSH Terms
Descriptor/Qualifier:
Breast / metabolism*
Colostrum / chemistry
Fatty Acids / analysis,  biosynthesis*,  blood
Female
Humans
Labor, Obstetric / physiology
Lactation / physiology*
Pregnancy
Grant Support
ID/Acronym/Agency:
HD-20833/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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