Document Detail


Human malignant glioma cell lines are refractory to retinoic acid-mediated differentiation and sensitization to apoptosis.
MedLine Citation:
PMID:  10878446     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Retinoids are candidate differentiation-inducing agents for glial tumors. Differentiation therapy is an attractive approach to cancers that resist surgery, irradiation and chemotherapy. METHODS: We examined the effects of retinoids on proliferation, morphology and sensitivity to apoptosis in human malignant glioma and neuroblastoma cell lines. RESULTS: In contrast to neuroblastoma cells, retinoids are devoid of acute cytotoxic effects and have only moderate antiproliferative effects on human glioma cell lines upon long-term exposure at high concentrations. Electron microscopy fails to reveal features of differentiation or apoptosis in retinoid-treated glioma cells and untransformed rat astrocytes. Retinoids do not modulate CD95 or CD95L expression or susceptibility to CD95-mediated apoptosis and fail to act in synergy with interferon (IFN)-alpha or IFN-gamma or cancer chemotherapy drugs to promote growth inhibition or apoptosis. CONCLUSION: Glioma cell lines are refractory to the induction of differentiation or apoptosis by retinoids.
Authors:
F Schmidt; P Groscurth; J Dichgans; M Weller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology     Volume:  10     ISSN:  1015-8987     ISO Abbreviation:  Cell. Physiol. Biochem.     Publication Date:  2000  
Date Detail:
Created Date:  2000-10-19     Completed Date:  2000-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9113221     Medline TA:  Cell Physiol Biochem     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  159-68     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel.
Affiliation:
Laboratory of Molecular Neuro-Oncology, Department of Neurology, University of Tübingen, School of Medicine, Tübingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Astrocytes / drug effects
Cell Differentiation
Drug Interactions
Glioma / drug therapy*,  pathology
Humans
Interferon-alpha / pharmacology
Interferon-gamma / pharmacology
Proto-Oncogene Proteins c-bcl-2 / metabolism
Rats
Stereoisomerism
Tretinoin / pharmacology*
Tumor Suppressor Protein p53 / metabolism
Chemical
Reg. No./Substance:
0/Interferon-alpha; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Suppressor Protein p53; 302-79-4/Tretinoin; 82115-62-6/Interferon-gamma

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