| Human lysozyme (origin and distribution in health and disease). | |
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MedLine Citation:
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PMID: 366724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Histochemical and in particular immunoperoxidase techniques have extended our knowledge about the cellular distribution of LZM. The enzyme has been detected in: 1. granulocytes, which synthesize LZM in bone marrow; 2. cells of the mononuclear phagocytic system, which synthesize LZM continuously; 3. various exocrine glands, whose LZM is probably in part synthesized locally and in part derived from blood; 4. cartilage, which probably synthesizes LZM and 5. the kidney, in which LZM is serum-derived. In pathological conditions, such as inflammation and neoplasia, most LZM-positive cells at the site of disease are either granulocytes or members of the mono-nuclear phagocytic system. A notable exception are the metaplastic Paneth cells that occur along the gastrointestinal tract in inflammation and neoplasia. LZM is an antibacterial agent, but evidence is accumulating which suggests that the enzyme might have other functions as well. |
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Authors:
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S Reitamo; M Klockars; M Adinolfi; E F Osserman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: La Ricerca in clinica e in laboratorio Volume: 8 ISSN: 0390-5748 ISO Abbreviation: Ric Clin Lab Publication Date: 1978 Oct-Dec |
Date Detail:
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Created Date: 1979-03-28 Completed Date: 1979-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613947 Medline TA: Ric Clin Lab Country: ITALY |
Other Details:
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Languages: eng Pagination: 211-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast / enzymology Cartilage / enzymology Ear, Middle / enzymology Exocrine Glands / enzymology Female Fetus / enzymology Granulocytes / enzymology Histocytochemistry Humans Immunoenzyme Techniques Inflammation / enzymology Intestinal Mucosa / enzymology Kidney / enzymology Lactation Male Monocytes / enzymology Muramidase / biosynthesis, metabolism* Myeloproliferative Disorders / enzymology Neoplasms / enzymology Pregnancy Respiratory System / enzymology Salivary Glands / enzymology Semen / enzymology Skin / enzymology Stomach / enzymology |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.17/Muramidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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