Document Detail

Human lymphocytes bear membrane receptors for C3b and C3d.
MedLine Citation:
PMID:  4543024     Owner:  NLM     Status:  MEDLINE    
Human peripheral blood lymphocytes have membrane receptors for EAC43b (sheep erythrocytes sensitized with antibody and complement) and also for EAC43d, obtained by treating EAC43b with C3b inactivator. Human granulocytes bind only EAC43b, C3 fragments obtained by limited trypsin digestion of purified human C3 display both C3b and C3d sites, since they inhibit rosette formation of lymphocytes with EAC43b and EAC43d. These findings raise the possibility that C3b and C3d receptor sites may be selectively distributed among normal subpopulations of B lymphocytes as well as among leukemic leukocytes.
A Eden; G W Miller; V Nussenzweig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  52     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1973 Dec 
Date Detail:
Created Date:  1974-01-11     Completed Date:  1974-01-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3239-42     Citation Subset:  AIM; IM    
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MeSH Terms
Antibody Specificity
Antigen-Antibody Complex
B-Lymphocytes / immunology*
Binding Sites*
Cell Membrane / immunology
Complement System Proteins*
Erythrocytes / immunology
Immune Adherence Reaction
Sheep / immunology
Reg. No./Substance:
0/Antigen-Antibody Complex; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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