Document Detail


Human lymphocyte binding and deiodination of thyroid hormones in relation to thyroid function.
MedLine Citation:
PMID:  171899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human lymphocyte has been investigated regarding its function as a thyroid hormone target cell. Binding and deiodination of the thyroid hormones were determined after simultaneous incubation of 131I-labelled L-thyroxine (131I-T4) and 125I-labelled L-triiodothyronine (125I-T3) with lymphocytes from healthy subjects, from hyperthyroid and primary hypothyroid patients before and after treatment. The mean percentages of binding, 8.0 +/- 0.5 (mean +/- SEM) for 131I-T4, and 9.7 +/- 0.4 for 125I-T3 in the control group, were increased in the hyperthyroids to 10.1 +/- 0.4 and 12.7 +/- 0.6 respectively, and in the hypothyroids to 10.9 +/- 0.7 and 12.8 +/- 0.6. All elevated values returned to normal with successful treatment. The mean percentage of deiodination, 12.0 +/- 1.7 for 131I-T4, and 6.5 +/- 0.9 for 125I-T3 in the control group, showed a threefold increase in the hyperthyroid patients, to 35.9 +/- 3.2 and 20.2 +/- 1.9 respectively and remained unaltered in the hypothyroid patients. The values of successfully treated hyperthyroid patients were normal and those of the treated hypothyroid patients below normal.
Authors:
A C Holm; T Lemarchand-Béraud; B R Scazziga; S Cuttelod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  80     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-01-16     Completed Date:  1976-01-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  642-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Humans
Hyperthyroidism / blood*,  drug therapy
Hypothyroidism / blood*,  drug therapy
Iodine Radioisotopes
Lymphocytes / metabolism*
Middle Aged
Receptors, Cell Surface / drug effects
Stimulation, Chemical
Temperature
Thyrotropin / pharmacology,  therapeutic use
Thyroxine / blood*
Triiodothyronine / blood*
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Receptors, Cell Surface; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

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