Document Detail


Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients.
MedLine Citation:
PMID:  23319432     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although alpha-fetoprotein is currently the major serologic biomarker for hepatocellular carcinoma (HCC), it cannot efficiently distinguish this cancer from other forms of liver disease in early diagnosis due to its low sensitivity. The aim of this study is to compare human carboxylesterase 1 (hCE1) biomarker sensitivity and specificity versus alpha-fetoprotein (AFP). Antibody-based assays for hCE1 and AFP were used to test both biomarkers with respect to diagnostic efficiency, Youden's index, and the area under the curve (AUC) through receiver operating characteristic (ROC) analysis in plasma from 208 patients with HCC (n=57), liver cirrhosis (n=27), chronic hepatitis (n=37), cholangiocarcinoma (n=22), gastric cancer (n=31), and pancreatic cancer (n=34), along with 52 healthy donors. The levels of hCE1 were significantly higher in patients with HCC than healthy donors and the other diseases (p < 0.005), further verified by AUC values and Youden's index. In the set of HCC versus liver cirrhosis the AUC values were 0.744 (AFP), 0.918 (hCE1), and 0.938 (combination of AFP and hCE1), respectively. These results indicate that hCE1 is not only a more potent and specific marker in distinguishing cancer from liver diseases, in particular cirrhosis, but the combination of hCE1 and AFP shows also synergistic potential for greater sensitivity and specificity in early diagnosis. Therefore the antibody-based hCE1 assay appears to have high diagnostic efficiency for discriminating HCC from other forms of liver disease. It is now feasible to further validate this novel plasma-based biomarker in the large cohort we assembled. © 2013 Wiley Periodicals, Inc.
Authors:
Keun Na; Seul-Ki Jeong; Min-Jung Lee; Sang Yun Cho; Sun A Kim; Min-Ji Lee; Si Young Song; Hoguen Kim; Kyung Sik Kim; Hyun Woong Lee; Young-Ki Paik
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-15
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 UICC.
Affiliation:
Yonsei Proteome Reasearch Center and Yonsei University, Seoul, Korea; Graduate Program in Functional Genomics Yonsei University, Seoul, Korea.
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