| Human leukocyte antigens polymorphism among Chinese patients with chronic plaque psoriasis: subgroup analysis. | |
| | |
MedLine Citation:
|
PMID: 21985130 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: Human leukocyte antigen (HLA) -Cw*06 has a strong influence on the clinical features and the susceptibility of psoriasis in different ethnicity. It is also used as a biomarker to predict the therapeutic efficacy of biologics with inconsistent results. Additionally, most Asian patients with psoriasis do not carry HLA-Cw*06. Aim: To determine additional HLA alleles which confer the susceptibility or affect the severity of psoriasis in Chinese Han. In addition, the potential of using HLA to predict treatment outcomes was also investigated. Materials and methods: We conducted a case-control association study in 199 Chinese patients with psoriasis and 200 unrelated healthy controls. HLA-B and -C genotyping was performed and correlated with the therapeutic efficacy of the biologics, including alefacept, efalizumab, etanercept and ustekinumab. Patients with psoriasis were divided into group A (high-need patients with moderate to severe psoriasis) and B (general psoriasis patients). Results: The frequencies of HLA-B*60, -B*75, -Cw*06, -Cw*10 were significantly increased in patients with psoriasis compared with the healthy controls. However, the prevalence of HLA-Cw*06 was lower in group A compared with group B (6% vs. 17%, Pc = 0.04). HLA-B*46 was found to be strongly associated with group A but not with group B psoriasis patients. HLA-Cw*01-B*46 was also identified as a risk haplotype for Chinese psoriasis patient, compatible with the results in Thais. Significant differences in the response to biologics was observed between HLA-Cw*01+ and HLA-Cw*01- in the alefacept treatment group, and HLA-B*37+ and HLA-B*37-, HLA-B*58+ and HLA-B*58-, in the efalizumab treatment group. Conclusions: In addition to HLA-Cw*06, HLA-Cw*01-B*46 haplotype was also increased in Chinese patients with psoriasis. High-need psoriasis patients had a lower frequency of HLA-Cw*06 but a higher prevalence of HLA-B*46 compared to general psoriasis patients in our population. |
| | |
Authors:
|
H-Y Chiu; P-Y Huang; S-H Jee; C-Y Hu; C-T Chou; Y-T Chang; C-Y Hwang; T-F Tsai |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-10 |
Journal Detail:
|
Title: The British journal of dermatology Volume: - ISSN: 1365-2133 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 British Association of Dermatologists. |
Affiliation:
|
Department of Dermatology, National Taiwan University Hospital, Taipei, Taiwan Department of Laboratory Medicine, National Taiwan University Hospital and School of Medical Technology, College of Medicine, National Taiwan University, Taipei Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan Department of Dermatology, National Yang-Ming University, Taipei, Taiwan Section of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Indoloquinazoline alkaloids from Euodia rutaecarpa and their cytotoxic activities.
Next Document: Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma.