Document Detail


Human leukocyte antigens in childhood idiopathic nephrotic syndrome.
MedLine Citation:
PMID:  1801548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An association of human leukocyte antigens (HLA) with idiopathic nephrotic syndrome (INS) in childhood was studied to characterize the immunogenetic background. We determined the class I antigens using the microlymphocytotoxicity test as well as class II antigens (DRB, DQB, DQA) and class III antigen (complement 4) using DNA restriction fragment length polymorphism (RFLP) in 36 children with INS. In the current study, neither the single allele in HLA class I antigen nor the single gene frequency in the class II region was significantly increased, in contrast to the results in Caucasian INS patients in whom a genetic predisposition to the HLA system, especially to HLA B8, DR3, and DR7, has been frequently reported. Also, in our data, the frequency of deletion of complement 4 gene was not different from that of the controls. These data suggest that there is a difference in immunogenetic background between Caucasian and Japanese INS patients as far as HLA is concerned.
Authors:
D K Jin; T Kohsaka; M Tanaka; J Abe; N Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  33     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-04-22     Completed Date:  1992-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  709-13     Citation Subset:  IM    
Affiliation:
Department of Immunology, National Children's Medical Research Center, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Alleles
Asian Continental Ancestry Group / genetics
Child
European Continental Ancestry Group / genetics
HLA Antigens / genetics*
HLA-C Antigens / genetics
HLA-D Antigens / genetics
HLA-DR Antigens / genetics
Haplotypes
Humans
Japan
Leukocytes / immunology*
Nephrotic Syndrome / genetics,  immunology*
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-C Antigens; 0/HLA-D Antigens; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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