| Human leukocyte antigens in Gulf War veterans with chronic unexplained multiple symptoms. | |
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MedLine Citation:
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PMID: 14719628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several articles have suggested that immune dysregulation related to Gulf War deployment may be involved in chronic illnesses with an unclear etiology among Gulf War veterans. To determine whether genetic susceptibility related to the human leukocyte antigen (HLA) system might play a role in development of the veterans' illnesses, we examined the frequency distribution of HLA A, B, DR, and DQ antigens from symptomatic veterans residing in south-central Pennsylvania compared with a local healthy population database. Only HLA-A28 demonstrated statistical significance. A28 was present in 7 (21.9%) of 32 of the veterans and 15 (6.9%) of 217 of the healthy population (p = 0.01, Fisher's exact test). This accounts for a minority of the ill veterans tested and is not statistically significant when corrected for the number of antigens determined. We conclude that specific HLA antigens are not strongly associated with the illnesses of Gulf War veterans. |
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Authors:
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Thomas A O'Bryan; Paula J Romano; Bruce C Zangwill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Military medicine Volume: 168 ISSN: 0026-4075 ISO Abbreviation: Mil Med Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-01-14 Completed Date: 2004-02-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2984771R Medline TA: Mil Med Country: United States |
Other Details:
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Languages: eng Pagination: 1015-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of General Internal Medicine, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Female HLA Antigens / blood* Humans Male Persian Gulf Syndrome / blood, immunology* Pilot Projects Veterans* War |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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