Document Detail

Human leukocyte antigens in Gulf War veterans with chronic unexplained multiple symptoms.
MedLine Citation:
PMID:  14719628     Owner:  NLM     Status:  MEDLINE    
Several articles have suggested that immune dysregulation related to Gulf War deployment may be involved in chronic illnesses with an unclear etiology among Gulf War veterans. To determine whether genetic susceptibility related to the human leukocyte antigen (HLA) system might play a role in development of the veterans' illnesses, we examined the frequency distribution of HLA A, B, DR, and DQ antigens from symptomatic veterans residing in south-central Pennsylvania compared with a local healthy population database. Only HLA-A28 demonstrated statistical significance. A28 was present in 7 (21.9%) of 32 of the veterans and 15 (6.9%) of 217 of the healthy population (p = 0.01, Fisher's exact test). This accounts for a minority of the ill veterans tested and is not statistically significant when corrected for the number of antigens determined. We conclude that specific HLA antigens are not strongly associated with the illnesses of Gulf War veterans.
Thomas A O'Bryan; Paula J Romano; Bruce C Zangwill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Military medicine     Volume:  168     ISSN:  0026-4075     ISO Abbreviation:  Mil Med     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-02-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2984771R     Medline TA:  Mil Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1015-8     Citation Subset:  IM    
Department of Medicine, Division of General Internal Medicine, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
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MeSH Terms
Chronic Disease
HLA Antigens / blood*
Persian Gulf Syndrome / blood,  immunology*
Pilot Projects
Reg. No./Substance:
0/HLA Antigens

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