| Human leukocyte antigen frequency in human high-grade gliomas: a case-control study in Sicily. | |
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MedLine Citation:
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PMID: 19487887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Human leukocyte antigens (HLAs) are widely expressed cell surface molecules that present antigenic peptides to T lymphocytes and modulate immune response against inflammatory and malignant diseases. The aim of this study was to compare HLA distribution in patients with newly diagnosed high-grade gliomas (HGGs) and 2 control groups from a restricted geographic area (eastern Sicily). METHODS: HLA allele frequency, as determined from peripheral blood of 56 adult patients with HGGs, was compared with that of 2 different control groups: 140 healthy bone marrow donors (group A) and 69 virtually brain tumor-free patients (group B). HLA expression was evaluated using a reverse transcriptase polymerase chain reaction-sequence-specific oligonucleotide probe. RESULTS: There was significant expression of HLA-A*11 in patients with HGGs compared with control groups A and B (P < 0.003 and P < 0.018, respectively). Significant expression of HLA genotypes in patients with HGGs was also identified for HLA-DQB1*06 (P = 0.005), HLA-DRB1*14 (P = 0.001), and HLA-DRB3*01 (P = 0.007) compared with control group B. In HGG patients, there was statistically significantly decreased expression, compared with control groups A and B, of HLA-B*07 (P = 0.002 and P = 0.03, respectively) and HLA-C*04 (P = 0.007 and P = 0.016, respectively). There was statistically significant lower expression of HLA-C*05 in the HGG group compared with group B (P < 0.03). CONCLUSION: This is the first study to describe the frequency of distribution of HLAs in a population from a restricted geographic area. The findings suggest a possible correlation between HLA allele distribution and the occurrence of newly diagnosed malignant astroglial brain tumors. |
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Authors:
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Domenico La Torre; Rosario Maugeri; Filippo F Angileri; Gaetana Pezzino; Alfredo Conti; Salvatore M Cardali; Amedeo Calisto; Giuseppe Sciarrone; Aldo Misefari; Antonino Germanò; Francesco Tomasello |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurosurgery Volume: 64 ISSN: 1524-4040 ISO Abbreviation: Neurosurgery Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-02 Completed Date: 2009-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: United States |
Other Details:
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Languages: eng Pagination: 1082-8; discussion 1088-9 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of Messina, Messina, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Neoplasms / blood*, classification Case-Control Studies Chi-Square Distribution Confidence Intervals Female Gene Frequency Genetic Predisposition to Disease* Genotype Glioma / blood*, classification HLA Antigens / blood*, classification, genetics Humans Male Middle Aged Odds Ratio Retrospective Studies Sicily / ethnology |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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