Document Detail

Human leukocyte antigen frequency in human high-grade gliomas: a case-control study in Sicily.
MedLine Citation:
PMID:  19487887     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Human leukocyte antigens (HLAs) are widely expressed cell surface molecules that present antigenic peptides to T lymphocytes and modulate immune response against inflammatory and malignant diseases. The aim of this study was to compare HLA distribution in patients with newly diagnosed high-grade gliomas (HGGs) and 2 control groups from a restricted geographic area (eastern Sicily). METHODS: HLA allele frequency, as determined from peripheral blood of 56 adult patients with HGGs, was compared with that of 2 different control groups: 140 healthy bone marrow donors (group A) and 69 virtually brain tumor-free patients (group B). HLA expression was evaluated using a reverse transcriptase polymerase chain reaction-sequence-specific oligonucleotide probe. RESULTS: There was significant expression of HLA-A*11 in patients with HGGs compared with control groups A and B (P < 0.003 and P < 0.018, respectively). Significant expression of HLA genotypes in patients with HGGs was also identified for HLA-DQB1*06 (P = 0.005), HLA-DRB1*14 (P = 0.001), and HLA-DRB3*01 (P = 0.007) compared with control group B. In HGG patients, there was statistically significantly decreased expression, compared with control groups A and B, of HLA-B*07 (P = 0.002 and P = 0.03, respectively) and HLA-C*04 (P = 0.007 and P = 0.016, respectively). There was statistically significant lower expression of HLA-C*05 in the HGG group compared with group B (P < 0.03). CONCLUSION: This is the first study to describe the frequency of distribution of HLAs in a population from a restricted geographic area. The findings suggest a possible correlation between HLA allele distribution and the occurrence of newly diagnosed malignant astroglial brain tumors.
Domenico La Torre; Rosario Maugeri; Filippo F Angileri; Gaetana Pezzino; Alfredo Conti; Salvatore M Cardali; Amedeo Calisto; Giuseppe Sciarrone; Aldo Misefari; Antonino Germanò; Francesco Tomasello
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  64     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1082-8; discussion 1088-9     Citation Subset:  IM    
Department of Neurosurgery, University of Messina, Messina, Italy.
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MeSH Terms
Brain Neoplasms / blood*,  classification
Case-Control Studies
Chi-Square Distribution
Confidence Intervals
Gene Frequency
Genetic Predisposition to Disease*
Glioma / blood*,  classification
HLA Antigens / blood*,  classification,  genetics
Middle Aged
Odds Ratio
Retrospective Studies
Sicily / ethnology
Reg. No./Substance:
0/HLA Antigens

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