| Human leucocyte response to migration inhibitory activity from lymphocytes. Modification by aprotinin, Tranexamic acid and phenylmethyl sulfonylfluoride. | |
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MedLine Citation:
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PMID: 305717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human lymphokines can elicit several effects associated with inflammation, e.g. leucocyte migration inhibition and fibrinolysis. These effects can be assessed in vitro by the leucocyte migration agarose technique (LMAT) and the leucocyte migration fibrinolysis technique (LMFT). The present study shows that preincubation of normal leucocytes with aprotinin, tranexamic acid and phenyl-methyl-sulfonylfluoride (PMSF) reduces or abolishes their migration inhibition response to leucocyte migration inhibition factor. The compounds exert this effect at non-toxic concentrations, which do not otherwise interfere with migration or fibrinolysis, and are non-toxic as estimated by PHA stimulation of lymphocytes. The LMFT is more sensitive to the modifying effect than the LMAT. The effect of aprotinin and tranexamic acid is reversible, the effect of PMSF is irreversible. |
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Authors:
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E Coeugniet; B Søeberg; G Bendixen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica Volume: 203 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1978 |
Date Detail:
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Created Date: 1978-05-08 Completed Date: 1978-05-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aprotinin
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pharmacology* Cell Migration Inhibition Cell Movement* Cell Survival / drug effects Cells, Cultured Cyclohexanecarboxylic Acids / pharmacology* Fibrinolysis / drug effects Humans Leukocytes / drug effects, immunology* Lymphocyte Activation / drug effects Lymphocytes / immunology* Lymphokines / pharmacology Phenylmethylsulfonyl Fluoride / pharmacology* Sulfones / pharmacology* Tranexamic Acid / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cyclohexanecarboxylic Acids; 0/Lymphokines; 0/Sulfones; 1197-18-8/Tranexamic Acid; 329-98-6/Phenylmethylsulfonyl Fluoride; 9087-70-1/Aprotinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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