Document Detail


Human leucocyte response to migration inhibitory activity from lymphocytes. Modification by aprotinin, Tranexamic acid and phenylmethyl sulfonylfluoride.
MedLine Citation:
PMID:  305717     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human lymphokines can elicit several effects associated with inflammation, e.g. leucocyte migration inhibition and fibrinolysis. These effects can be assessed in vitro by the leucocyte migration agarose technique (LMAT) and the leucocyte migration fibrinolysis technique (LMFT). The present study shows that preincubation of normal leucocytes with aprotinin, tranexamic acid and phenyl-methyl-sulfonylfluoride (PMSF) reduces or abolishes their migration inhibition response to leucocyte migration inhibition factor. The compounds exert this effect at non-toxic concentrations, which do not otherwise interfere with migration or fibrinolysis, and are non-toxic as estimated by PHA stimulation of lymphocytes. The LMFT is more sensitive to the modifying effect than the LMAT. The effect of aprotinin and tranexamic acid is reversible, the effect of PMSF is irreversible.
Authors:
E Coeugniet; B Søeberg; G Bendixen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  203     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1978  
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aprotinin / pharmacology*
Cell Migration Inhibition
Cell Movement*
Cell Survival / drug effects
Cells, Cultured
Cyclohexanecarboxylic Acids / pharmacology*
Fibrinolysis / drug effects
Humans
Leukocytes / drug effects,  immunology*
Lymphocyte Activation / drug effects
Lymphocytes / immunology*
Lymphokines / pharmacology
Phenylmethylsulfonyl Fluoride / pharmacology*
Sulfones / pharmacology*
Tranexamic Acid / pharmacology*
Chemical
Reg. No./Substance:
0/Cyclohexanecarboxylic Acids; 0/Lymphokines; 0/Sulfones; 1197-18-8/Tranexamic Acid; 329-98-6/Phenylmethylsulfonyl Fluoride; 9087-70-1/Aprotinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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