Document Detail

Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss.
MedLine Citation:
PMID:  22114131     Owner:  NLM     Status:  MEDLINE    
BACKGROUND The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during pregnancy. METHODS The literature on polymorphisms of the three genes, expression patterns of the proteins, and interactions with immune cell receptors have been evaluated to elucidate whether HLA-E, -F and -G are involved in the pathogenesis of some cases of recurrent miscarriages and unexplained infertility. RESULTS AND CONCLUSIONS The HLA class Ib molecules seem to induce suppression of the maternal immune system, but are not necessarily fundamental factors for pregnancy success. However, evidence points towards low expression of these proteins, especially HLA-G, being associated with reduced fertility. To clarify the functions of HLA-E, -F and -G future studies need to link investigations of the polymorphisms in these genes to measurements of protein levels, and examine the role of these proteins in the complex interplay of immune cells and cytokines at the materno-fetal interface.
Mette Dahl; Thomas Vauvert F Hviid
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-11-23
Journal Detail:
Title:  Human reproduction update     Volume:  18     ISSN:  1460-2369     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-08-16     Revised Date:  2012-11-29    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  92-109     Citation Subset:  IM    
Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, Copenhagen University Hospital (Roskilde), Region Sjælland, Roskilde, Denmark.
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MeSH Terms
Abortion, Habitual / immunology*
Histocompatibility Antigens Class I / blood,  genetics,  physiology*
Histocompatibility, Maternal-Fetal*
Infertility, Female / immunology
Maternal-Fetal Exchange
Models, Immunological
Polymorphism, Genetic
Pregnancy Outcome
Reg. No./Substance:
0/Histocompatibility Antigens Class I

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