| Human leucocyte antigen class Ib molecules in pregnancy success and early pregnancy loss. | |
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MedLine Citation:
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PMID: 22114131 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUNDThe human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during pregnancy.METHODSThe literature on polymorphisms of the three genes, expression patterns of the proteins, and interactions with immune cell receptors have been evaluated to elucidate whether HLA-E, -F and -G are involved in the pathogenesis of some cases of recurrent miscarriages and unexplained infertility.RESULTS AND CONCLUSIONSThe HLA class Ib molecules seem to induce suppression of the maternal immune system, but are not necessarily fundamental factors for pregnancy success. However, evidence points towards low expression of these proteins, especially HLA-G, being associated with reduced fertility. To clarify the functions of HLA-E, -F and -G future studies need to link investigations of the polymorphisms in these genes to measurements of protein levels, and examine the role of these proteins in the complex interplay of immune cells and cytokines at the materno-fetal interface. |
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Authors:
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Mette Dahl; Thomas Vauvert F Hviid |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-23 |
Journal Detail:
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Title: Human reproduction update Volume: - ISSN: 1460-2369 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9507614 Medline TA: Hum Reprod Update Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, Copenhagen University Hospital (Roskilde), Region Sjælland, 7-13 Køgevej, DK-4000 Roskilde, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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