| Human leucocyte antigen-Bw4 and Gag-specific T cell responses are associated with slow disease progression in HIV-1B-infected anti-retroviral therapy-naive Chinese. | |
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MedLine Citation:
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PMID: 23379436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In China, the majority of human immunodeficiency virus (HIV) infections are predominately subtype B. It is important to characterize the HIV-1 subtype B-specific and its T cell response within the Chinese population, with the aim of identifying protective correlates of immunity to control HIV-1 infections. In this study, we performed a comprehensive analysis looking into the magnitude/strength of T cell responses directed at the Gag protein of the HIV-1 subtype B, one of the most conserved HIV-1 proteins. The study group consisted of anti-retroviral native and chronic HIV-1 subtype B-infected individuals. We used enzyme-linked immunospot (ELISPOT) assay to quantify the total T cell responses to HIV-1 Gag at the single peptide level. Twenty-eight (38%) peptides were recognized in 24 (82·8%) individuals. The p24 was identified as the most frequently recognized subunit protein with the greatest T cell response in the test, which correlated positively with CD4(+) T cell count and inversely with viral load (VL). At the level of the human leucocyte antigen (HLA) supertypes, we detected the highest levels and a significant correlation with both the CD4(+) T cell count and the VL with Gag T cell responses in Bw4/Bw4. These findings demonstrate that (i) the HIV-1B Gag p24-specific immune responses play an important role in controlling viral replication and slowing clinical progression; and (ii) HLA-Bw4/Bw4 allele has stronger T cell responses, which is associated with slow clinical progression in Chinese HIV patients. |
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Authors:
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W-H Li; C-Y Li; H-B Yang; H-P Zhang; X Zhang; L-S Kong; X-N Xu; S-C Lu; H-P Yan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 171 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-05 Completed Date: 2013-04-02 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 298-306 Citation Subset: IM |
Copyright Information:
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© 2012 British Society for Immunology. |
Affiliation:
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YouAn Hospital, Capital Medical University, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acid Sequence Disease Progression* Enzyme-Linked Immunospot Assay Female HIV Infections / drug therapy, immunology*, physiopathology, virology* HIV-1 / classification, immunology* HLA-B Antigens / immunology* Humans Male Middle Aged Molecular Sequence Data T-Lymphocytes / immunology* gag Gene Products, Human Immunodeficiency Virus / immunology* |
| Chemical | |
Reg. No./Substance:
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0/HLA-B Antigens; 0/HLA-Bw4 antigen; 0/gag Gene Products, Human Immunodeficiency Virus |
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