| Human keratinocytes express AIM2 and respond to dsDNA with IL-1β secretion. | |
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MedLine Citation:
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PMID: 22092578 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Keratinocytes have been recognized to actively participate in the skin immune response. It has been shown that keratinocytes express all components that are necessary to form the NLRP3 inflammasome complex including the adapter protein ASC and caspase-1. In this study, we investigated the presence and activity of the recently identified absent in melanoma 2 (AIM2) inflammasome in human keratinocytes. We were able to show that an AIM2 inflammasome is active in human keratinocytes. IL-1 production by keratinocytes plays a pivotal role in inflammatory processes in the skin. Activation of the AIM2 inflammasome in keratinocytes represents another potential trigger factor for the development and maintenance of inflammatory skin diseases. |
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Authors:
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Verena Kopfnagel; Miriam Wittmann; Thomas Werfel |
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Publication Detail:
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Type: Letter |
Journal Detail:
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Title: Experimental dermatology Volume: 20 ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
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Languages: eng Pagination: 1027-9 Citation Subset: IM |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany Faculty of Biological Sciences, University of Leeds, Leeds, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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