Document Detail

Human intoxication with paralytic shellfish toxins: clinical parameters and toxin analysis in plasma and urine.
MedLine Citation:
PMID:  16238098     Owner:  NLM     Status:  MEDLINE    
This study reports the data recorded from four patients intoxicated with shellfish during the summer 2002, after consuming ribbed mussels (Aulacomya ater) with paralytic shellfish toxin contents of 8,066 +/- 61.37 microg/100 gr of tissue. Data associated with clinical variables and paralytic shellfish toxins analysis in plasma and urine of the intoxicated patients are shown. For this purpose, the evolution of respiratory frequency, arterial blood pressure and heart rate of the poisoned patients were followed and recorded. The clinical treatment to reach a clinically stable condition and return to normal physiological parameters was a combination of hydration with saline solution supplemented with Dobutamine (vasoactive drug), Furosemide (diuretic) and Ranitidine (inhibitor of acid secretion). The physiological condition of patients began to improve after four hours of clinical treatment, and a stable condition was reached between 12 to 24 hours. The HPLC-FLD analysis showed only the GTX3/GTX2 epimers in the blood and urine samples. Also, these epimers were the only paralytic shellfish toxins found in the shellfish extract sample.
Carlos García; Marcelo Lagos; Dominique Truan; Karinna Lattes; Omar Véjar; Beatriz Chamorro; Verónica Iglesias; Darío Andrinolo; Néstor Lagos
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological research     Volume:  38     ISSN:  0716-9760     ISO Abbreviation:  Biol. Res.     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-21     Completed Date:  2006-03-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9308271     Medline TA:  Biol Res     Country:  Chile    
Other Details:
Languages:  eng     Pagination:  197-205     Citation Subset:  IM    
Laboratorio Bioquímica de Membrana. Depto. Fisología y Biofísica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
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MeSH Terms
Cardiotonic Agents / therapeutic use
Chromatography, High Pressure Liquid
Diuretics / therapeutic use
Dobutamine / therapeutic use
Foodborne Diseases / diagnosis,  drug therapy,  etiology*
Furosemide / therapeutic use
Hemodynamics / drug effects
Marine Toxins / blood*,  poisoning,  urine*
Middle Aged
Ranitidine / therapeutic use
Shellfish Poisoning*
Sodium Chloride / therapeutic use
Time Factors
Reg. No./Substance:
0/Cardiotonic Agents; 0/Diuretics; 0/Marine Toxins; 34368-04-2/Dobutamine; 54-31-9/Furosemide; 66357-35-5/Ranitidine; 7647-14-5/Sodium Chloride

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