Document Detail

Human in vivo study of the renin-angiotensin-aldosterone system and the sympathetic activity after 8 weeks daily intake of fermented milk.
MedLine Citation:
PMID:  20113315     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Milk fermented by lactic acid bacteria is suggested to have antihypertensive effect in humans. In vitro and animal studies have established an angiotensin-converting enzyme (ACE) inhibitor effect of peptides in fermented milk. However, other modes of action must be considered, because until today no human studies have confirmed an ACE inhibition in relation to the intake of fermented milk. MATERIALS AND METHODS: We undertook a double-blinded randomized placebo-controlled study including 94 borderline-hypertensive persons to study the effect on human physiology of Lactobacillus helveticus fermented milk. The subjects were randomized into three groups: Cardi04-300 ml, Cardi04-150 ml or placebo. All components of the renin-angiotensin-aldosterone system were measured several times. Sympathetic activity was estimated by plasma noradrenaline and cardiovascular response to head-up tilt at baseline and after 8 weeks of intervention. RESULTS: No ACE inhibition of the fermented milk was demonstrated, as none of the components of the renin-angiotensin-aldosteron system changed. Plasma noradrenaline response to tilt test after intervention stayed unchanged between groups (P = 0.38), but declined in the group Cardi04-300 from 2.01 +/- 0.93 nmol l(-1) at baseline to 1.49 +/- 0.74 nmol l(-1) after 8 weeks (P = 0.002). There was no change in 24-h ambulatory blood pressure or heart rate between groups. CONCLUSIONS: Despite a known ACE inhibitory effect in vitro and in animals, milk fermented with Lb. helveticus did not inhibit ACE in humans. Our results suggest that the intake of fermented milk decreases sympathetic activity, although not to an extent mediating reductions of blood pressure and heart rate in borderline-hypertensive subjects.
Lotte Usinger; Hans Ibsen; Allan Linneberg; Michel Azizi; Bénédicte Flambard; Lars T Jensen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-01-26
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  30     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  162-8     Citation Subset:  IM    
Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital Glostrup, Glostrup, Denmark.
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MeSH Terms
Antihypertensive Agents / administration & dosage
Blood Pressure / drug effects,  physiology
Cultured Milk Products*
Hypertension / drug therapy*,  physiopathology
Lactobacillus helveticus
Middle Aged
Milk Proteins / administration & dosage*
Norepinephrine / blood
Peptides / administration & dosage
Renin-Angiotensin System / drug effects*,  physiology
Sympathetic Nervous System / drug effects*,  physiology
Tilt-Table Test
Reg. No./Substance:
0/Antihypertensive Agents; 0/Milk Proteins; 0/Peptides; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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