| Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy. | |
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MedLine Citation:
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PMID: 22192680 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Clin Microbiol Infect ABSTRACT: We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naïve patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets. |
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Authors:
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M Franzetti; M Violin; G Casazza; G Meini; A Callegaro; P Corsi; F Maggiolo; A R Pignataro; S Paolucci; N Gianotti; D Francisci; R Rossotti; G Filice; T Carli; M Zazzi; C Balotta |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-28 |
Journal Detail:
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Title: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Volume: - ISSN: 1469-0691 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516420 Medline TA: Clin Microbiol Infect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases. |
Affiliation:
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Department of Clinical Sciences 'L. Sacco', Section of Infectious Diseases and Immunopathology, University of Milan, Milan Unit of Statistics and Biometry, University of Milan, Milan Department of Biotechnology, University of Siena, Siena Department of Microbiology and Virology, 'Ospedali Riuniti', Bergamo Department of Infectious Diseases, 'Careggi' Hospital, Florence Department of Infectious Diseases, 'Ospedali Riuniti', Bergamo Department of Virology, San Raffaele Scientific Institute, Milan Molecular Virology Unit, Fondazione IRCCS Policlinico 'San Matteo', Pavia Department of Infectious Diseases, San Raffaele Scientific Institute, Milan Infectious Diseases Clinic, University of Perugia, Perugia Infectious Diseases Clinic, 'A Manzoni' Hospital, Lecco Department of Infectious Diseases, Fondazione IRCCS Policlinico 'San Matteo', Pavia Department of Infectious Diseases, 'Misericordia' Hospital, Grosseto, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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