Document Detail


Human hexosaminidase isozymes. IV. Effects of oral contraceptive steroids on serum hexosaminidase activity.
MedLine Citation:
PMID:  463955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Data from a mass screening program for identification of persons who are heterozygous for Tay-Sachs disease have been analyzed for the effects of oral contraceptive steroids on the activity in serum of hexosaminidase (hex) and the various hex isozymes. Women using oral contraceptives show a significantly higher total serum hex activity, reflecting mainly an increase in the heat-stable hex isozyme (hex I), and a smaller increase in the heat-labile hex A than do women using no medications. The changes in women using oral contraceptives are qualitatively similar to those observed during pregnancy. The distribution of responses to oral contraceptives is unimodal, and some of the variations may be related to differences in amount of steroid ingested. In addition, underlying genetic variation may contribute to the observed differences in enzyme activities.
Authors:
H M Nitowsky; J Davis; S Nakagawa; D Fox
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  134     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  642-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chromatography, DEAE-Cellulose
Contraceptives, Oral / pharmacology*
Female
Heterozygote Detection
Hexosaminidases / blood*
Humans
Isoenzymes / blood*
Mass Screening
Middle Aged
New York
New York City
Tay-Sachs Disease / enzymology*,  epidemiology,  prevention & control
Chemical
Reg. No./Substance:
0/Contraceptives, Oral; 0/Isoenzymes; EC 3.2.1.-/Hexosaminidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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