| Human hexosaminidase isozymes. IV. Effects of oral contraceptive steroids on serum hexosaminidase activity. | |
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MedLine Citation:
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PMID: 463955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Data from a mass screening program for identification of persons who are heterozygous for Tay-Sachs disease have been analyzed for the effects of oral contraceptive steroids on the activity in serum of hexosaminidase (hex) and the various hex isozymes. Women using oral contraceptives show a significantly higher total serum hex activity, reflecting mainly an increase in the heat-stable hex isozyme (hex I), and a smaller increase in the heat-labile hex A than do women using no medications. The changes in women using oral contraceptives are qualitatively similar to those observed during pregnancy. The distribution of responses to oral contraceptives is unimodal, and some of the variations may be related to differences in amount of steroid ingested. In addition, underlying genetic variation may contribute to the observed differences in enzyme activities. |
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Authors:
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H M Nitowsky; J Davis; S Nakagawa; D Fox |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 134 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-09-17 Completed Date: 1979-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 642-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chromatography, DEAE-Cellulose Contraceptives, Oral / pharmacology* Female Heterozygote Detection Hexosaminidases / blood* Humans Isoenzymes / blood* Mass Screening Middle Aged New York New York City Tay-Sachs Disease / enzymology*, epidemiology, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral; 0/Isoenzymes; EC 3.2.1.-/Hexosaminidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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