| Human herpesvirus 6A infects human embryonic fibroblasts and induces G2/M arrest and cell death. | |
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MedLine Citation:
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PMID: 22337306 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Human herpesvirus 6 (HHV-6) is a beta-herpesvirus capable of infecting cells from different origin. In this study, infection with HHV-6A of human embryonic fibroblasts (HEFs) was performed. Infected cells showed obvious cytopathic effects (CPE). PCR and immunohistochemical tests also confirmed that HEFs are susceptible to HHV-6A infection. The biological effects of HHV-6A infection on HEFs were studied. Infected cells showed decreased proliferation as measured by [(3) H] thymidine incorporation and cell counting. Further analysis demonstrated that infection with HHV-6A leads to cell cycle arrest at G2/M phase and increasing cell death. This is the first demonstration that infection of HEFs with HHV-6A causes profound alterations of cell properties. J. Med. Virol. 84:657-663, 2012. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Lingyun Li; Bin Gu; Feng Zhou; Jing Chi; Fang Wang; Genyan Liu; Chuanlin Ding; Fangyi Xie; Jian Qing; Yidi Guo; Kun Yao |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical virology Volume: 84 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-02-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
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Languages: eng Pagination: 657-63 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, China; Department of Developmental Genetics, Nanjing Medical University, Nanjing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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