| Human herpesvirus-6: neurologic implications of a newly-described viral pathogen. | |
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MedLine Citation:
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PMID: 9839645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Discovered only 12 years ago, human herpesvirus-6 (HHV-6) has been associated with central nervous system (CNS) findings such as febrile seizures, encephalitis, meningitis, and possibly multiple sclerosis. These manifestations have been reported in both immunocompetent and immunocompromised individuals. The applications of such sophisticated laboratory tools as polymerase chain reaction, in situ hybridization, immunohistochemical staining, and representational difference analysis have expanded knowledge of the spectrum of CNS disease attributable to HHV-6 while delineating pathogenic mechanisms of both primary HHV-6 infection and reactivation from latency. This article reviews existing knowledge of the CNS manifestations of HHV-6, focusing on both clinical aspects of HHV-6 infection and its pathogenesis on neurologic diseases. |
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Authors:
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D W Kimberlin; R J Whitley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of neurovirology Volume: 4 ISSN: 1355-0284 ISO Abbreviation: J. Neurovirol. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-01-29 Completed Date: 1999-01-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9508123 Medline TA: J Neurovirol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 474-85 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, The University of Alabama at Birmingham, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Central Nervous System Diseases / virology* Child Herpesviridae Infections* / complications, epidemiology, transmission, virology Herpesvirus 6, Human* / pathogenicity, physiology Humans Immunocompromised Host Meningoencephalitis / virology Multiple Sclerosis / virology Seizures / virology |
| Grant Support | |
ID/Acronym/Agency:
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N01-AI-62554/AI/NIAID NIH HHS; P01 AI 24009/AI/NIAID NIH HHS; RR-032/RR/NCRR NIH HHS |
| Comments/Corrections | |
Comment In:
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J Neurovirol. 1998 Oct;4(5):471-3
[PMID:
9839644
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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