| Human herpesvirus 6 infections after liver transplantation. | |
| | |
MedLine Citation:
|
PMID: 19496184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Human herpesvirus 6 (HHV-6) infections occur in > 95% of humans. Primary infection, which occurs in early childhood as an asymptomatic illness or manifested clinically as roseola infantum, leads to a state of subclinical viral persistence and latency. Reactivation of latent HHV-6 is common after liver transplantation, possibly induced and facilitated by allograft rejection and immunosuppressive therapy. Since the vast majority of humans harbor the virus in a latent state, HHV-6 infections after liver transplantation are believed to be mostly due to endogenous reactivation or superinfection (reactivation in the transplanted organ). In a minority of cases, however, primary HHV-6 infection may occur when an HHV-6 negative individual receives a liver allograft from an HHV-6 positive donor. The vast majority of documented HHV-6 infections after liver transplantation are asymptomatic. In a minority of cases, HHV-6 has been implicated as a cause of febrile illness with rash and myelosuppression, hepatitis, pneumonitis, and encephalitis after liver transplantation. In addition, HHV-6 has been associated with a variety of indirect effects such as allograft rejection, and increased predisposition and severity of other infections including cytomegalovirus (CMV), hepatitis C virus, and opportunistic fungi. Because of the uncommon nature of the clinical illnesses directly attributed to HHV-6, there is currently no recommended HHV-6-specific approach to prevention. However, ganciclovir and valganciclovir, which are primarily intended for the prevention of CMV disease, are also active against HHV-6 and may prevent its reactivation after transplantation. The treatment of established HHV-6 disease is usually with intravenous ganciclovir, cidofovir, or foscarnet, complemented by reduction in the degree of immunosuppression. This article reviews the current advances in the pathogenesis, clinical diagnosis, and therapeutic modalities against HHV6 in the setting of liver transplantation. |
| | |
Authors:
|
Rima Camille Abdel Massih; Raymund R Razonable |
Related Documents
:
|
15600244 - Selecting antifungal agents for the treatment of invasive fungal infections in patients... 10702724 - Viral dynamics during active cytomegalovirus infection and pathology. 21099744 - Impact of a preemptive strategy after 3 months of valganciclovir cytomegalovirus prophy... 11015394 - Comparison of the cmv brite turbo assay and the digene hybrid capture cmv dna (version ... 3300814 - Erythropoietin production by the fetal liver in an adult environment. 8074604 - Intravenous immunoglobulin-induced osmotic nephrosis. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 15 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-04 Completed Date: 2009-08-17 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 2561-9 Citation Subset: IM |
Affiliation:
|
Division of Infectious Diseases, Department of Medicine, and the William J von Liebig Transplant Center, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antiviral Agents
/
adverse effects,
therapeutic use Herpesviridae Infections / diagnosis, drug therapy, immunology, physiopathology* Herpesvirus 6, Human / immunology, pathogenicity* Humans Immunosuppressive Agents / adverse effects, therapeutic use Liver Transplantation / adverse effects*, immunology Postoperative Complications / immunology, virology* Virus Activation |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Immunosuppressive Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Second International Conference on Accelerating Biopharmaceutical Development: March 9-12, 2009, Cor...
Next Document: Nutritional status and nutritional therapy in inflammatory bowel diseases.