Document Detail


Human herpesvirus-6 genomes in histiocytic necrotizing lymphadenitis (Kikuchi's disease) and other forms of lymphadenitis.
MedLine Citation:
PMID:  8388164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cervical lymph nodes of 27 patients with histiocytic necrotizing lymphadenitis (HNL) were examined, as were those of 9 patients with tuberculous lymphadenitis (Tb), 10 with reactive paracortical hyperplasia (RPH), and 10 with nonspecific lymphadenitis (NSL). Southern blot analysis, the polymerase chain reaction (PCR), and in situ hybridization were use to locate the human herpesvirus-6 (HHV-6) genome. Southern blot analysis showed that all cases were negative for HHV-6 genomes, although all but one HNL case expressed HHV-6 genome using PCR. On in situ hybridization all 10 HNL cases, 6 of the 10 RPH cases, 6 of the 10 NSL cases, and 2 of the 9 Tb cases showed HHV-6 DNA. These results indicate that the presence of HHV-6 genome is not specifically related to HNL, and that this virus could hibernate in a latent form in the cervical lymph nodes. In addition, we examined three different primers (A, B, and C) for PCR amplification of HHV-6 genomes.
Authors:
Y Sumiyoshi; M Kikuchi; K Ohshima; S Yoneda; S Kobari; M Takeshita; Y Eizuru; Y Minamishima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  99     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-11     Completed Date:  1993-06-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-14     Citation Subset:  AIM; IM    
Affiliation:
First Department of Pathology, School of Medicine, Fukuoka University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Base Sequence
Biopsy
Blotting, Southern
Child
Child, Preschool
DNA, Viral / genetics*
Female
Genome, Viral*
Herpesvirus 6, Human / genetics*
Humans
In Situ Hybridization
Lymph Nodes / microbiology,  pathology
Lymphadenitis / classification,  genetics*
Male
Middle Aged
Molecular Sequence Data
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/DNA, Viral
Comments/Corrections
Comment In:
Am J Clin Pathol. 1993 May;99(5):533-5   [PMID:  8388159 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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