Document Detail

Human herpesvirus-6 genomes in histiocytic necrotizing lymphadenitis (Kikuchi's disease) and other forms of lymphadenitis.
MedLine Citation:
PMID:  8388164     Owner:  NLM     Status:  MEDLINE    
The cervical lymph nodes of 27 patients with histiocytic necrotizing lymphadenitis (HNL) were examined, as were those of 9 patients with tuberculous lymphadenitis (Tb), 10 with reactive paracortical hyperplasia (RPH), and 10 with nonspecific lymphadenitis (NSL). Southern blot analysis, the polymerase chain reaction (PCR), and in situ hybridization were use to locate the human herpesvirus-6 (HHV-6) genome. Southern blot analysis showed that all cases were negative for HHV-6 genomes, although all but one HNL case expressed HHV-6 genome using PCR. On in situ hybridization all 10 HNL cases, 6 of the 10 RPH cases, 6 of the 10 NSL cases, and 2 of the 9 Tb cases showed HHV-6 DNA. These results indicate that the presence of HHV-6 genome is not specifically related to HNL, and that this virus could hibernate in a latent form in the cervical lymph nodes. In addition, we examined three different primers (A, B, and C) for PCR amplification of HHV-6 genomes.
Y Sumiyoshi; M Kikuchi; K Ohshima; S Yoneda; S Kobari; M Takeshita; Y Eizuru; Y Minamishima
Related Documents :
665174 - Cervical adeno-carcinoma and partial hydatidiform mole.
3794964 - Osteochondroma of the cervical spine.
7067354 - The significance of osteophytes on lumbar vertebral bodies in relation to discographic ...
19680734 - Case report: absent c6 cervical pedicle in a collegiate football player.
15136394 - Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomi...
11817394 - Untoward neonatal sequelae deriving from cutting of the umbilical cord before delivery.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  99     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-11     Completed Date:  1993-06-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  609-14     Citation Subset:  AIM; IM    
First Department of Pathology, School of Medicine, Fukuoka University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Base Sequence
Blotting, Southern
Child, Preschool
DNA, Viral / genetics*
Genome, Viral*
Herpesvirus 6, Human / genetics*
In Situ Hybridization
Lymph Nodes / microbiology,  pathology
Lymphadenitis / classification,  genetics*
Middle Aged
Molecular Sequence Data
Polymerase Chain Reaction
Reg. No./Substance:
0/DNA, Viral
Comment In:
Am J Clin Pathol. 1993 May;99(5):533-5   [PMID:  8388159 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  bcl-2 expression in Hodgkin's disease. Correlation with the t(14;18) translocation and Epstein-Barr ...
Next Document:  A translocation (8;14) in a cutaneous large B-cell lymphoma.