Document Detail

Human herpesvirus-6 encephalitis after unrelated cord blood transplantation.
MedLine Citation:
PMID:  16019484     Owner:  NLM     Status:  MEDLINE    
Here we describe 2 patients with acute leukemia in whom human herpesvirus-6 (HHV-6) encephalitis developed after cord blood transplantation. In patients 1 and 2, generalized seizure and coma developed on day 62 and day 15, respectively, after cord blood transplantation, which failed to engraft in patient 1. Magnetic resonance imaging (MRI) of patient 1's brain showed low-intensity signals at the gyri of the bilateral lateral lobes on T1-weighted images and high-intensity signals on T2-weighted images. MRI of patient 2's brain showed high-intensity signals in bilateral white matter on T2-weighted images and on fluid-attenuated inversion recovery (FLAIR) images. Cerebrospinal fluid examination revealed an increased protein level with pleocytosis in patient 1 and a normal protein level without pleocytosis in patient 2. Polymerase chain reaction analysis detected HHV-6 DNA in the cerebrospinal fluid of both patients. Patient 1 recovered after administration of gancyclovir for 3 weeks. However, she again suffered from encephalitis after discontinuation of gancyclovir, and died of sepsis. Patient 2 died from an anoxic brain caused by generalized seizure. When neurological symptoms and signs appear in hematopoietic stem cell transplantation recipients, we should consider HHV-6 encephalitis and promptly and empirically treat them with gancyclovir or foscarnet.
M Tanaka; J Taguchi; R Hyo; T Kawano; C Hashimoto; S Motomura; F Kodama; S Kobayashi; G Okabe; A Maruta; T Nagao; Y Ishigatsubo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  46     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  561-6     Citation Subset:  IM    
Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
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MeSH Terms
Cord Blood Stem Cell Transplantation / adverse effects*
Encephalitis, Viral / cerebrospinal fluid,  diagnosis*,  etiology
Fatal Outcome
Herpesvirus 6, Human*
Leukemia, Monocytic, Acute / therapy*
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy*
Roseolovirus Infections / cerebrospinal fluid,  diagnosis*,  etiology

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