| Human herpesvirus 6 and effectiveness of interferon beta 1b in multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 21518144 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: Human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) have been repeatedly associated with multiple sclerosis (MS) pathogenesis. Also, it has been speculated that, besides its immunomodulatory properties, the efficacy of interferon beta (IFN-beta) in treating the disease may be related to its antiviral properties. The objectives of this study were to evaluate the in vivo antiviral effect of IFN-beta-1b over HHV-6 and EBV and to analyze whether such effect could be involved in its effectiveness in MS. Methods: A total of 54 patients with MS were included in an observational, multicentric, 24-month study. HHV-6 and EBV were detected by qPCR in blood and serum samples. IFN-beta-1b effectiveness was evaluated by presence, number and severity of relapses, reduction in the relapse rate, disability progression, and response to the treatment. Results: Patients with HHV-6 in blood had a higher risk of severe relapses (P = 0.01) and bad response (P = 0.03). HHV-6 was detected more frequently during relapses than in remission in blood (P = 0.024) and in serum (P = 0.0002). Patients with HHV-6 in serum had more relapses (P = 0.02), lesser reduction in the relapse rate (P = 0.04), and a lower proportion of responders (P = 0.02) than those without HHV-6 active replication. However, any association between EBV and clinical parameters could not be found. Conclusions: We concluded that presence of HHV-6 in blood and serum during IFN-beta treatment could be a good marker of poor response. |
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Authors:
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M Garcia-Montojo; V De Las Heras; M Dominguez-Mozo; M Bartolome; M A Garcia-Martinez; R Arroyo; R Alvarez-Lafuente; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-25 |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: - ISSN: 1468-1331 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Author(s). European Journal of Neurology © 2011 EFNS. |
Affiliation:
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Unidad de Esclerosis Múltiple, Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain. |
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