| Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance? | |
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MedLine Citation:
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PMID: 10194079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebrospinal fluid (CSF) specimens from 22 allogeneic bone marrow transplant patients with central nervous system (CNS) symptoms (cases) and 107 patients who were immunocompromised but did not have CNS symptoms (controls) were assayed for human herpesvirus 6 (HHV-6) DNA. HHV-6 DNA was detected in CSF specimens from five (23%) of 22 cases and in CSF specimens from one (0.9%) of 107 controls (P < .001, Fisher's exact test). In addition, none of the five cases with HHV-6 DNA detected in CSF samples had any other identified cause of their CNS symptoms, and none of the other 11 cases with known causes for their CNS diseases had HHV-6 DNA detected in CSF samples (P = .03, Fisher's exact test). In three cases, HHV-6 variant B was identified, and the HHV-6 variant could not be defined in the other two cases. Prophylaxis with acyclovir did not prevent the occurrence of HHV-6-associated CNS disease after allogeneic bone marrow transplantation. Four cases' conditions were improved or they were cured after treatment with either ganciclovir or foscarnet, and one case died of CNS disease despite foscarnet treatment. |
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Authors:
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F Z Wang; A Linde; H Hägglund; M Testa; A Locasciulli; P Ljungman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 28 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-06-24 Completed Date: 1999-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 562-8 Citation Subset: IM |
Affiliation:
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BMT Program, Huddinge University Hospital, Karolinska Institute, Sweden. Fu-Zhang.Wang@smi.ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Marrow Transplantation / adverse effects* Case-Control Studies Central Nervous System Infections / diagnosis, epidemiology, virology* Cerebrospinal Fluid / virology Child Child, Preschool DNA, Viral / cerebrospinal fluid* Female Herpesviridae Infections / virology* Herpesvirus 6, Human / isolation & purification* Humans Incidence Infant Male Middle Aged Polymerase Chain Reaction / methods |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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