Document Detail

Human hepatic infarction: histopathological and postmortem angiological studies.
MedLine Citation:
PMID:  8259035     Owner:  NLM     Status:  MEDLINE    
Twenty hepatic infarction cases selected from 5420 consecutive autopsy cases were investigated to clarify the pathogenetic aspects of this disease. Additional postmortem angiological studies of 24 normal human livers obtained at autopsy were also further performed to analyse the effects of blocking vascular structures on lesion development. Seventeen of the 20 cases (85%) were clinically associated with systemic circulatory insufficiency, especially hepato- and/or renal failure. Histopathologically, there was a significantly closer relationship between the location of infarcted regions and portal vein thrombosis than with either hepatic vein thrombosis or hepatic arterial damage. The borders between infarcted regions and surviving hepatic parenchyma were located around central veins, corresponding with the microcirculatory periphery of the portal venous system. Postmortem angiographic studies revealed that hepatic lobuli mainly consist of portal vein branches. Moreover, postmortem embolization studies of six normal livers using glass beads and barium-gelatin injection showed that physical occlusion of portal vein branches produced defects in broad areas of the hepatic parenchyma. Therefore, it is suggested that the development of hepatic infarction principally depends on disturbances of the portal venous system. In addition, systemic circulatory insufficiency, which reduces the intrahepatic blood flow, probably contributes greatly to the development of hepatic infarction.
M Saegusa; Y Takano; M Okudaira
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Liver     Volume:  13     ISSN:  0106-9543     ISO Abbreviation:  Liver     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8200939     Medline TA:  Liver     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  239-45     Citation Subset:  IM    
Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Aged, 80 and over
Hepatic Artery / pathology
Hepatic Veins / pathology
Infant, Newborn
Infarction / pathology*
Liver / blood supply*,  pathology*
Middle Aged
Portal Vein / pathology

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