Document Detail

Human health risk assessment of organochlorines associated with fish consumption in a coastal city in China.
MedLine Citation:
PMID:  15809117     Owner:  NLM     Status:  MEDLINE    
Food consumption is an important route of human exposure to organochlorines (OCs). In order to assess the potential health risks associated with these contaminants due to fish consumption, five species of fish were collected from a local market in Zhoushan City, an island in the East China Sea. Dioxin-like compounds, such as polychlorinated dibenzo-p-dioxins/ dibenzofurans, in the fish samples were screened by H4IIE-luc cell bioassay, and the concentrations of specific organochlorines were measured by gas chromatograph-electron capture detector (GC-ECD). The bioassay results indicated that concentrations of dioxin-like compounds in the fish samples were below detection limit (0.64 pg/mL). The concentrations of OC pesticides and PCBs ranged from 0.67 to 13 and 0.24 to 1.4 ng/g wet wt., respectively. Significantly, concentrations of p,p'-DDE in fish meat were comparatively high (average 3.9 ng/g wet wt.) compared with the other OC pesticides. The daily fish consumption, based on a dietary survey conducted among 160 local healthy residents, was determined to be 105 g/person. The relevant cancer benchmark concentrations of HCB, dieldrin, chlordane, DDTs and PCBs were 0.36, 0.04, 1.6, 1.7, and 0.29 ng/kg per day, respectively, based on the local diet. The hazard ratios (HRs), based on non-cancer endpoints were all less than 1.0, while the HRs based on cancer were greater than 1.0 for certain contaminants based on the 95th centile concentration in fish tissue.
Q T Jiang; T K M Lee; K Chen; H L Wong; J S Zheng; J P Giesy; K K W Lo; N Yamashita; P K S Lam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  136     ISSN:  0269-7491     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-04-05     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  155-65     Citation Subset:  IM    
Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong.
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MeSH Terms
Biological Assay
Chromatography, Gas / methods
Dioxins / toxicity
Food Contamination*
Health Status
Hydrocarbons, Chlorinated / toxicity*
Neoplasms / chemically induced
Oceans and Seas
Pesticide Residues / toxicity*
Polychlorinated Biphenyls / toxicity
Risk Assessment
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/Dioxins; 0/Hydrocarbons, Chlorinated; 0/Pesticide Residues; 0/Polychlorinated Biphenyls; 0/Water Pollutants, Chemical

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