| Human growth hormone induces and maintains c-myc gene expression in Nb2 lymphoma cells. | |
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MedLine Citation:
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PMID: 4065045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of human GH (hGH) on c-myc gene expression and cell proliferation in the Nb2 lymphoma cell line was examined. The addition of hormone to stationary cultures of Nb2 cells resulted in an increased accumulation of c-myc transcripts that was detectable within 15 min, reached a maximum induction of 25-fold in 3 h, and then gradually declined. Although maximal accumulation of c-myc transcripts occurred within 3 h after hGH addition, removal of the hormone even after 4 h of treatment resulted in a failure of the cells to proliferate. This loss of proliferative capacity following hormone removal was accompanied by a 20-fold reduction in the level of c-myc transcripts. These results indicate that hGH induced proliferation of Nb2 cells is associated with the induction and maintenance of c-myc gene expression. |
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Authors:
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W H Fleming; P R Murphy; L J Murphy; T W Hatton; R J Matusik; H G Friesen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrinology Volume: 117 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1985-12-27 Completed Date: 1985-12-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2547-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Division Cell Line Gene Expression Regulation / drug effects* Growth Hormone / pharmacology* Humans Lymphoma / genetics* Oncogenes* RNA, Messenger / metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HDO7843-13/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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