Document Detail


Human granulocytic ehrlichiosis in Wisconsin and Minnesota: a frequent infection with the potential for persistence.
MedLine Citation:
PMID:  8603945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human granulocytic ehrlichiosis (HGE) is a tickborne illness caused by an agent closely related to Ehrlichia equi and Ehrlichia phagocytophila. The clinical presentation is nonspecific, and diagnosis is made infrequently. Sixty-six sera were obtained from 54 patients in Minnesota and Wisconsin with undifferentiated fever during the summer and fall of 1993. Serologic reactivity with E. equi was observed in 6 (11%), including 4 seroconversions, 1 stable titer, and 1 seroreversion. Of the seropositive patients, HGE agent DNA was detected by polymerase chain reaction in the first serum from 4 of 5 patients and was present in the serum of 1 of 2 untreated patients after 21 days, even when E. equi antibodies also were present. HGE is a significant and potentially frequent cause of undifferentiated fever in Wisconsin and Minnesota during seasons with tick activity. The agent may persist in untreated patients for at least 1 months or may be cleared earlier, even if not treated with doxycycline or tetracycline.
Authors:
J S Dumler; J S Bakken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  173     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-05-16     Completed Date:  1996-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1027-30     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, University of Maryland School of Medicine, Baltimore, 21287, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Antibodies, Bacterial / analysis
Chronic Disease
DNA, Bacterial / analysis
Ehrlichiosis / diagnosis,  epidemiology*
Granulocytes / immunology*
Humans
Minnesota
Wisconsin
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/DNA, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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