Document Detail


Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology.
MedLine Citation:
PMID:  15088079     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Norepinephrine (NE) is a key neurotransmitter in the central and peripheral nervous systems. Dopamine beta-hydroxylase (DbetaH) catalyzes the synthesis of NE from dopamine (DA) and occurs in the plasma as a stable heritable trait. Studies of this trait have been useful in psychiatric and neurological research. OBJECTIVE: To selectively and critically review the literature on plasma DbetaH, and on recent progress understanding the molecular genetic basis for its inheritance. Based on this review, directions for future research in psychiatry and neurology will be suggested. METHODS: We selectively review the literature on the biochemical and molecular genetics of plasma DbetaH activity, as well as research on plasma and cerebrospinal fluid (CSF) DbetaH in psychiatric and neurological disorders. RESULTS: Strong evidence implicates DBH, the structural locus encoding DbetaH enzyme, as the major quantitative trait locus influencing plasma DbetaH activity, with one single nucleotide polymorphism (SNP) accounting for up to 50% of the variance. Mutations at DBH appear to be responsible for the rare syndrome of DbetaH deficiency. Some biochemical and genetic studies suggest associations between low plasma or CSF DbetaH and psychotic symptoms in several psychiatric disorders. Studies combining genotyping at DBH with biochemical measurement of plasma DbetaH have proven useful in studies of schizophrenia, cocaine-induced paranoia (CIP), depression, attention deficit hyperactivity disorder, and alcoholism. Such studies may also elucidate the contribution of noradrenergic dysfunction to a variety of symptoms in Parkinson's disease and other degenerative neurological disorders. CONCLUSIONS: A model is proposed, in which lower levels of DbetaH protein may lead to elevated ratios of DA to NE. This model may explain associations between lower plasma DbetaH activity and vulnerability to psychotic symptoms. Genotype-controlled analysis of plasma DbetaH holds promise for promoting further progress in research on psychiatric and neurological disorders.
Authors:
J F Cubells; C P Zabetian
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2004-04-16
Journal Detail:
Title:  Psychopharmacology     Volume:  174     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-04     Completed Date:  2004-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  463-76     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, 950 Campbell Avenue, West Haven, CT 06516, USA. jcubells@genetics.emory.edu
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MeSH Terms
Descriptor/Qualifier:
Alcohol-Induced Disorders / blood,  genetics
Dopamine beta-Hydroxylase / blood,  deficiency,  genetics*
Genotype
Humans
Mental Disorders / genetics
Models, Neurological
Neurodegenerative Diseases / blood,  genetics
Neurology
Psychiatry
Research
Grant Support
ID/Acronym/Agency:
K02 DA 15766/DA/NIDA NIH HHS; K08 NS 44138/NS/NINDS NIH HHS; K12 DA 00089/DA/NIDA NIH HHS; R01 DA 12422/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
EC 1.14.17.1/Dopamine beta-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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