| Human genetic approaches to diseases of lymphocyte activation. | |
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MedLine Citation:
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PMID: 18795237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our laboratory focuses on the study of the molecular regulation of T lymphocyte homeostasis, particularly as it relates to immunological tolerance, apoptosis, and autoimmune diseases. Through intense molecular research on the regulation of lymphocyte fate, the Fas receptor and other tumor necrosis factor receptors as well as their ligands have emerged as key regulators of T lymphocyte apoptosis. We are studying genetic abnormalities of this death pathway, particularly in the context of autoimmune lymphoproliferative syndrome (ALPS) and other non-ALPS conditions affecting lymphocyte homeostasis. These studies have led to further investigations of the regulation of the NF-kappaB signaling pathway, the molecular basis for programed cell death and viral cytopathicity, mechanisms of autoimmunity, and the regulation of mature T-cell tolerance. Our investigations promise to provide insight into the molecular mechanisms behind the regulation of immune response and contribute to the development of novel diagnostic and treatment methods for autoimmune diseases. |
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Authors:
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Madhavi Prabhakar; Michael J Lenardo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunologic research Volume: 43 ISSN: 0257-277X ISO Abbreviation: Immunol. Res. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-26 Completed Date: 2009-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 8-14 Citation Subset: IM |
Affiliation:
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Molecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases. National Institutes of Health, Building 10, Room 11N311, 10 Center Drive, MSC 1892, Bethesda, MD 20892-1892, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / genetics, immunology Autoimmune Diseases / genetics*, immunology Autoimmunity / genetics, immunology Cytopathogenic Effect, Viral / genetics, immunology Humans Immune Tolerance / genetics, immunology Lymphocyte Activation / genetics*, immunology Lymphoproliferative Disorders / classification, genetics*, immunology NF-kappa B / genetics*, immunology Signal Transduction / genetics, immunology T-Lymphocyte Subsets / immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/NF-kappa B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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