Document Detail

Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2.
MedLine Citation:
PMID:  9790757     Owner:  NLM     Status:  MEDLINE    
KNSL4 (Kid; kinesin-like DNA-binding protein) is a member of the kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Myc-associated zinc finger protein (MAZ) participates in both the initiation and the termination of transcription of target genes. We isolated genomic DNA clones that encoded KNSL4 and MAZ from a human cosmid library. Sequence analysis revealed that the two genes were very close to one another. The distance between the two genes was only 1. 2 kb, and this intervening 1.2-kb region was extremely GC-rich. The gene for KNSL4 spanned 16 kb and consisted of 14 exons and 13 introns, while the gene for MAZ spanned 6 kb and consisted of 5 exons and 4 introns. The two genes were mapped to chromosome 16p11.2 by fluorescence in situ hybridization.
J Song; H Murakami; Z Q Yang; C Koga; N Adati; T Murata; C Geltinger; F Saito-Ohara; T Ikeuchi; M Matsumura; K Itakura; I Kanazawa; K Sun; K K Yokoyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  52     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-07     Completed Date:  1998-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Copyright Information:
Copyright 1998 Academic Press.
RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki, 305-0074, Japan.
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MeSH Terms
Chromosome Mapping
Chromosomes, Human, Pair 16 / genetics*
Cloning, Molecular
DNA-Binding Proteins / genetics*
In Situ Hybridization, Fluorescence
Kinesin / genetics*
Molecular Sequence Data
RNA Splicing / genetics
Restriction Mapping
Sequence Analysis, DNA
Transcription Factors / genetics*
Zinc Fingers / genetics
Reg. No./Substance:
0/DNA-Binding Proteins; 0/KIF22 protein, human; 0/Transcription Factors; 0/c-MYC-associated zinc finger protein; EC 3.6.1.-/Kinesin

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