Document Detail


Human gastroepiploic artery has greater chymase activity than the internal thoracic artery.
MedLine Citation:
PMID:  17070693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Recent reports have demonstrated that long-term patency of the gastroepiploic artery (GEA) in coronary artery bypass grafting (CABG) is less satisfactory compared with the internal thoracic artery (ITA). However, the reason has not been fully elucidated. Angiotensin II is known to play an important role in the development of intimal hyperplasia, we hypothesized that the GEA is different from the ITA with respect to angiotensin II-forming ability. Accordingly, we measured activities of angiotensin II-forming enzymes, angiotensin-converting enzyme (ACE) and chymase, in human GEA and ITA.
METHODS: Remnant of the GEAs and ITAs were obtained from 24 patients who underwent CABG in which both conduits were used simultaneously. Activities of ACE and chymase were measured by using the extract form the GEA or ITA. Sections of the GEA or ITA were immunohistochemically stained with anti-human chymase antibody.
RESULTS: The ACE activity of the GEA (0.28+/-0.16 mU/mg protein) was greater than that of the ITA (0.18+/-0.11, p < 0.001). The chymase activity of the GEA (11.11+/-7.15 mU/mg protein) was also greater than that in the ITA (7.13+/-4.89, p < 0.001). The density of chymase-positive cells in the GEA (3.8+/-4.2 cells/mm2) was greater than that in the ITA (1.1+/-1.2, p < 0.01).
CONCLUSION: Activities of both ACE and chymase were significantly greater in the GEA compared with the ITA. The GEA may be different from the ITA with respect to potential ability of angiotensin II-formation.
Authors:
Yoshiharu Soga; Shinji Takai; Hitoshi Okabayashi; Atsushi Nagasawa; Tadaaki Yokota; Kazunobu Nishimura; Mizuo Miyazaki; Masashi Komeda
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Publication Detail:
Type:  Journal Article     Date:  2006-10-27
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  30     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-02-28     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  877-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Chymases / metabolism*
Coronary Artery Bypass
Female
Gastroepiploic Artery / enzymology*,  pathology
Humans
Immunoenzyme Techniques
Internal Mammary-Coronary Artery Anastomosis
Male
Mammary Arteries / enzymology*,  pathology
Middle Aged
Peptidyl-Dipeptidase A / metabolism
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.21.39/Chymases

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