Document Detail


Human fibrinopeptide A mediates allergic reaction in mice in the acute phase.
MedLine Citation:
PMID:  11514036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We detected a human humoral peptide that deglycosylates mouse antibody IgE, and found that this peptide had the amino acid sequence ADSGEGDFLAEGGGV. The peptide synthesized according to the sequence also deglycosylated the antibody IgE. The deglycosylated IgE did not induce mouse systemic anaphylaxis. Human fibrinopeptide A has the amino acid sequence indicated above, and a polypeptide extracted from human urine showed an antiallergic effect on humans and mice, which strongly suggests that fibrinopeptide A mediates allergic reaction via antibody IgE-deglycosylation, and is excreted as a polypeptide in urine.
Authors:
Y Masuda; T Sugiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  22     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-12-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1511-3     Citation Subset:  IM    
Affiliation:
Psychosomatic Division, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acute-Phase Reaction / immunology*
Adult
Amino Acid Sequence
Animals
Drug Hypersensitivity / genetics,  immunology*
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Female
Fibrinopeptide A / pharmacology*
Glycosylation
Glycosyltransferases / chemical synthesis,  chemistry,  pharmacology
Humans
Hypersensitivity / immunology
Immune Sera
Immunoglobulin E / chemistry,  immunology,  isolation & purification
Injections, Intraperitoneal
Male
Mice
Mice, Inbred Strains
Molecular Sequence Data
Ovalbumin / administration & dosage,  pharmacology
Peptide Fragments / chemical synthesis,  chemistry,  pharmacology*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Immune Sera; 0/Peptide Fragments; 25422-31-5/Fibrinopeptide A; 37341-29-0/Immunoglobulin E; 9006-59-1/Ovalbumin; EC 2.4.-/Glycosyltransferases; EC 2.4.1.-/peptide P; EC 2.4.1.-/peptide Q glycosylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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