Document Detail

Human fetoplacental and fetal liver blood flow after maternal glucose loading: a cross-sectional observational study.
MedLine Citation:
PMID:  24806823     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To study umbilical vein and fetal liver blood flow related to fetal anthropometric measures following maternal oral glucose loading.
DESIGN: Experimental design in a cross-sectional observational study.
SETTING: University hospital.
POPULATION: 113 low-risk pregnancies (30 - 32 gestational weeks).
METHODS: Ultrasound Doppler measurements of umbilical vein and ductus venosus blood flow (ml/min) before and two hours after completed 75 g oral glucose tolerance test (OGTT). Liver blood flow was defined as the umbilical vein blood flow minus ductus venosus blood flow.
MAIN OUTCOME MEASURES: Changes in umbilical vein and fetal liver blood flow following OGTT related to fetal biometric measurements.
RESULTS: In the fasting state, fetal abdominal circumference z-scores did not correlate with any of the flow parameters. 120 min after glucose loading, the z-scores correlated positively with the changes in umbilical vein (r = 0.25, p = 0.010) and fetal liver blood flow (r = 0.25, p = 0.009), but not with those in ductus venosus (p = 0.84). In simultaneous multiple linear regression analyses, the effects of the changes in umbilical vein or fetal liver blood flow after OGTT on the fetal abdominal circumference z-scores were almost equal to or greater than other parameters related to fetal size (body mass index, fasting plasma glucose, parity, and sex). Fetal heart rate increased after OGTT, but did not influence the association between the blood flow parameters and fetal abdominal circumference z-scores.
CONCLUSIONS: Changes in umbilical vein and fetal liver blood flow after glucose loading were positively related to fetal abdominal size. This article is protected by copyright. All rights reserved.
Guttorm Haugen; Jens Bollerslev; Tore Henriksen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-8
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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