Document Detail

Human fetal albumin synthesis rates during different periods of gestation.
MedLine Citation:
PMID:  18842786     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite nutritional intervention, albumin concentrations are often low in critically ill premature neonates. OBJECTIVE: Our aim was to quantify albumin synthesis rates during early life under physiologic circumstances. Human fetuses thereby reflect the developmentally related optimal condition. DESIGN: Pregnant women undergoing elective cesarean delivery received 3 different labeled amino acid infusions starting at different times before surgery. With the use of mass spectrometry techniques, this novel model enabled us to quantify fetal albumin synthesis from a single blood sample taken from the umbilical cord after cesarean delivery. The fractional synthesis rate reflects the fraction of the albumin pool that is daily renewed. The absolute synthesis rate is the absolute amount of albumin that is daily synthesized. Results are expressed as medians (25th-75th percentile). RESULTS: We studied 8 fetuses at 29.9 (28.4-35.4) weeks of gestation and 8 fetuses around term. Fractional synthesis rates in premature fetuses [17.5 (12.1-24.4) %/d] were higher (P = 0.02) than in mature fetuses [10.4 (9.1-13.7) %/d]. Absolute synthesis rates were also higher (P = 0.02) in premature than in mature fetuses: 280 (227-365) versus 205 (184-238) mg . kg(-1) . d(-1). CONCLUSIONS: On a weight basis, albumin synthesis rates in premature fetuses were higher than in fetuses at term and were higher than the rates previously found in neonates after preterm birth. Considering that the premature fetal liver can synthesize albumin at a high rate, the observed hypoalbuminemia in premature infants therefore seems to suggest that current (nutritional) therapies fail to meet requirements necessary to sustain optimum albumin synthesis rates.
Chris H P van den Akker; Henk Schierbeek; Trinet Rietveld; Andras Vermes; Johannes J Duvekot; Eric A P Steegers; Johannes B van Goudoever
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  88     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-09     Completed Date:  2008-11-04     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  997-1003     Citation Subset:  AIM; IM    
Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.
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MeSH Terms
Carbon Isotopes
Cesarean Section
Fetal Blood / metabolism
Fetus / metabolism*
Gestational Age*
Hypoalbuminemia / etiology*
Infant Nutritional Physiological Phenomena
Infant, Newborn / metabolism*
Infant, Premature / metabolism
Nitrogen Isotopes
Nutritional Requirements*
Serum Albumin / biosynthesis*
Time Factors
Reg. No./Substance:
0/Carbon Isotopes; 0/Nitrogen Isotopes; 0/Serum Albumin

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