Document Detail


Human fatty liver disease: old questions and new insights.
MedLine Citation:
PMID:  21700865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are limited. Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies.
Authors:
Jonathan C Cohen; Jay D Horton; Helen H Hobbs
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  332     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-24     Completed Date:  2011-07-06     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1519-23     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dietary Fats / administration & dosage
Disease Models, Animal
Disease Progression
Fatty Liver* / etiology,  genetics,  metabolism,  pathology
Female
Genetic Predisposition to Disease
Humans
Insulin Resistance
Liver / metabolism,  pathology
Liver Cirrhosis / etiology
Liver Neoplasms / etiology
Male
Obesity
Triglycerides / metabolism
Grant Support
ID/Acronym/Agency:
P01 HL020948-35/HL/NHLBI NIH HHS; P01 HL20948/HL/NHLBI NIH HHS; R01 DK090066/DK/NIDDK NIH HHS; RL1 HL092550-05/HL/NHLBI NIH HHS; RL1HL092550/HL/NHLBI NIH HHS; UL1 DE019584-05/DE/NIDCR NIH HHS; UL1DE109584/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Triglycerides
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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