| Human fatty liver disease: old questions and new insights. | |
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MedLine Citation:
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PMID: 21700865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are limited. Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies. |
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Authors:
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Jonathan C Cohen; Jay D Horton; Helen H Hobbs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 332 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-24 Completed Date: 2011-07-06 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1519-23 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Fats / administration & dosage Disease Models, Animal Disease Progression Fatty Liver* / etiology, genetics, metabolism, pathology Female Genetic Predisposition to Disease Humans Insulin Resistance Liver / metabolism, pathology Liver Cirrhosis / etiology Liver Neoplasms / etiology Male Obesity Triglycerides / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01 HL020948-35/HL/NHLBI NIH HHS; P01 HL20948/HL/NHLBI NIH HHS; R01 DK090066/DK/NIDDK NIH HHS; RL1 HL092550-05/HL/NHLBI NIH HHS; RL1HL092550/HL/NHLBI NIH HHS; UL1 DE019584-05/DE/NIDCR NIH HHS; UL1DE109584/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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