Document Detail


Human exposure to indoor residential cyfluthrin residues during a structured activity program.
MedLine Citation:
PMID:  12679791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Estimations of absorbed daily dosage (ADD) of chemicals following contact with treated surfaces may be required for risk assessment and risk management. Measurements of ADD based upon biomonitoring are a more reliable data than estimates of ADD from environmental measurements since they require fewer default assumptions. Study participants performed a structured activity program (SAP) 24-h after an application of Tempo((R)) 20 WP (cyfluthrin; 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid cyano(4-fluoro-3-phenoxy-phenyl)-methyl ester) on a medium pile, plush nylon carpet. Measurements of total cyfluthrin residue and transferable cyfluthrin residue (cotton cloth and CDFA roller; personal sock and short dosimetry) were made at 3, 7, 12, 23, 47.5, and 407.5 h. Total cyfluthrin residue extracted from (Soxhlet extraction) carpet was 11.1+/-2.7 microg/cm(2) 1 h prior to the SAP. Transferable cyfluthrin residue obtained through analysis of cotton cloths rolled with a weighted 30-pound cylinder was 0.11 microg/cm(2). Cyfluthrin residues from socks and shorts were 0.74+/-0.23 and 0.15+/-0.03 microg/cm(2), respectively. Urine was collected at 12-h intervals during a 72-h period following the SAP and was analyzed for the cyfluthrin biomarker, 4-fluoro-3-phenoxybenzoic acid (FPBA). The mean cyfluthrin equivalents excreted were 8.4+/-5.7 microg/person (yielding an absorbed dosage of 0.10 microg/kg; n=7). The elimination half-life was 16+/-5 h. All predicted ADDs based upon environmental measurements overestimated the ADDs measured by urinary excretion.
Authors:
Ryan L Williams; Craig E Bernard; Robert I Krieger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of exposure analysis and environmental epidemiology     Volume:  13     ISSN:  1053-4245     ISO Abbreviation:  J Expo Anal Environ Epidemiol     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-07     Completed Date:  2003-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111438     Medline TA:  J Expo Anal Environ Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
Affiliation:
Personal Chemical Exposure Program, Department of Entomology, and Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, USA.
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MeSH Terms
Descriptor/Qualifier:
Air Pollution, Indoor
Environmental Exposure*
Floors and Floorcoverings
Half-Life
Humans
Insecticides / analysis*
Nitriles
Pesticide Residues / analysis*
Pyrethrins / analysis*
Risk Assessment
Chemical
Reg. No./Substance:
0/Insecticides; 0/Nitriles; 0/Pesticide Residues; 0/Pyrethrins; 68359-37-5/cyfluthrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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