Document Detail

Human epidermal growth factor receptor-2 and hormonal therapies: clinical implications.
MedLine Citation:
PMID:  12756077     Owner:  NLM     Status:  MEDLINE    
Estrogen-targeted therapies such as administration of tamoxifen or aromatase inhibitors are among the most important treatment strategies in the modern management of breast cancer. Despite initial responses in the metastatic setting and prolonged disease-free intervals in the adjuvant setting, many patients subsequently become resistant to these agents. Human epidermal growth factor receptor-2 (HER2) is a transmembrane glycoprotein receptor that is overexpressed in 13%-30% of human breast cancers. There are experimental data suggesting an important role for HER2 in de novo and acquired resistance to endocrine therapies. These experimental data are discussed in this article, as are clinical data addressing the role of HER2 in resistance to endocrine therapy in the adjuvant, neoadjuvant, and metastatic settings. Responses and benefit from tamoxifen appear to be impaired in patients in whom HER2 is overexpressed. In contrast, early data from the neoadjuvant setting suggest that responses to aromatase inhibitors may be maintained in patients with HER2 overexpression.
Alistair Ring; Mitch Dowsett
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical breast cancer     Volume:  4 Suppl 1     ISSN:  1526-8209     ISO Abbreviation:  Clin. Breast Cancer     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-20     Completed Date:  2005-11-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100898731     Medline TA:  Clin Breast Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S34-41     Citation Subset:  IM    
Department of Academic Biochemistry, Wallace Wing, Royal Marsden Hospital, London, United Kingdom.
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MeSH Terms
Antineoplastic Agents, Hormonal / pharmacology*,  therapeutic use
Aromatase Inhibitors / pharmacology*,  therapeutic use
Breast Neoplasms / drug therapy*,  metabolism
Chemotherapy, Adjuvant
Drug Resistance, Neoplasm / drug effects
Neoadjuvant Therapy
Randomized Controlled Trials as Topic
Receptor, Epidermal Growth Factor / drug effects,  metabolism*
Receptor, erbB-2 / drug effects,  metabolism*
Receptors, Estrogen / drug effects
Survival Analysis
Tamoxifen / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/Aromatase Inhibitors; 0/Receptors, Estrogen; 10540-29-1/Tamoxifen; EC, Epidermal Growth Factor; EC, erbB-2

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