Document Detail

Human epicardium: ultrastructural ancestry of mesothelium and mesenchymal cells.
MedLine Citation:
PMID:  19659734     Owner:  NLM     Status:  MEDLINE    
The human sub-epicardial area contains an unexplored cellular population under a layer of mesothelial cells. Transmission electron microscopy revealed the existence of interstitial Cajal-like cells (ICLCs), isolated smooth muscle cells (iSMC) and mesenchymal cells besides other well-known cells. The presence of iSMC in the sub-epicardial space is quite unique and could explain why epicardial-derived cells isolated from human epicardium generate smooth muscle cells in culture. Mesenchymal cells, guided by ICLCs, were found migrating from sub-epicardial area in the mesothelial layer. These findings suggest that epithelial-mesenchymal transition is not a common process involved in cardiac regeneration in vivo.
Mihaela Gherghiceanu; L M Popescu
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Publication Detail:
Type:  Journal Article     Date:  2009-07-29
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  13     ISSN:  1582-4934     ISO Abbreviation:  J. Cell. Mol. Med.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2949-51     Citation Subset:  IM    
Victor Babes National Institute of Pathology, Bucharest, Romania.
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MeSH Terms
Cell Movement
Cytoskeleton / ultrastructure
Epithelium / ultrastructure*
Mesoderm / cytology*,  ultrastructure*
Myocytes, Smooth Muscle / cytology,  ultrastructure
Pericardium / cytology*,  ultrastructure*

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