| Human eosinophil innate response to alternaria fungus through protease-activated receptor-2. | |
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MedLine Citation:
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PMID: 21646807 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Eosinophils are multifunctional leukocytes implicated in the pathogenesis of allergic diseases. An association between eosinophilic inflammation and infection or colonization by fungi has also been long recognized. However, the mechanisms underlying how eosinophils are activated and how they release proinflammatory and immunomodulatory mediators such as major basic protein (MBP) and eosinophil-derived neurotoxin remain largely unknown. We used a fungus, i.e. Alternaria, as a model microbe relevant to human asthma and chronic rhinosinusitis (CRS) to investigate the molecular mechanisms involved in the immune recognition of ubiquitous environmental allergens. Human eosinophils are activated by live Alternaria alternata organisms, release their granule proteins, and kill the fungi. Eosinophils, but not neutrophils, respond to secreted products from A. alternata. We found that eosinophils are equipped with innate cellular activation machinery that responds to an extracellular aspartate protease secreted by Alternaria. Aspartate protease activation of protease-activated receptor (PAR)-2 probably involves a novel mechanism different from that for serine protease activation of PAR-2. Thus, human eosinophils may recognize certain danger signals or virulence factors produced by fungi and provoke inflammatory responses against these organisms. Dysregulation of such an innate immune mechanism may be involved in the pathophysiology of certain human inflammatory diseases, including asthma and CRS. |
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Authors:
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Yoshinori Matsuwaki; Kota Wada; Hiroshi Moriyama; Hirohito Kita |
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Publication Detail:
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Type: Journal Article Date: 2011-06-01 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 155 Suppl 1 ISSN: 1423-0097 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan. matuwaki@jikei.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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