Document Detail


Human endogenous retrovirus K (HERV-K) rec mRNA is expressed in primary melanoma but not in benign naevi or normal skin.
MedLine Citation:
PMID:  23311654     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Human endogenous retroviruses (HERVs) are remnants of ancestral exogenous retroviral infections fixed in the germ-line DNA. Although no longer infectious, they may be transcriptionally active and have recently been implicated in melanomagenesis because of the observation of HERV-K mRNA and proteins in melanoma tissue and antibodies to HERV proteins in melanoma patients (Buscher et al., 2006; Buscher et al., 2005; Hahn et al., 2008; Muster et al., 2003; Singh et al., 2009b). Putative pathogenic mechanisms include disrupting host genes at their integration site, suppressing or stimulating immune responses or expressing potentially oncogenic proteins (Kurth and Bannert, 2010; Singh et al., 2009b). © 2013 John Wiley & Sons A/S.
Authors:
Sarita Singh; Steve Kaye; Nick Francis; David Peston; Martin Gore; Myra McClure; Christopher Bunker
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Publication Detail:
Type:  LETTER     Date:  2013-1-12
Journal Detail:
Title:  Pigment cell & melanoma research     Volume:  -     ISSN:  1755-148X     ISO Abbreviation:  Pigment Cell Melanoma Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101318927     Medline TA:  Pigment Cell Melanoma Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Affiliation:
Department of Dermatology, Imperial College School of Medicine, Chelsea and Westminster Hospital Campus, 369, Fulham Road, London, SW10 9NH, United Kingdom; Department of Infectious Diseases, Imperial College School of Medicine, Jefferiss Trust Laboratories, Wright Fleming Institute, St Mary's Campus, Norfolk Place, London, W2 1PG, United Kingdom.
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