Document Detail

Human cytomegalovirus glycoprotein B genotype correlates with different symptoms of infected infants.
MedLine Citation:
PMID:  17356299     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Human cytomegalovirus (HCMV) is the pathogen of cytomegalic inclusion disease of infants. HCMV strains can be classified into four genotypes of glycoprotein B (gB). There are limited data concerning links between clinical symptoms and HCMV genotypes. The aims of the present study were to determine the genotype of HCMV isolates from pediatric patients who have different symptoms on the assumption that the gB genotype may influence the outcomes of congenital and prenatal HCMV infection. METHODS: The gB types of HCMV were determined in urine specimens from 208 infected infants using nested polymerase chain reaction and restriction fragment length polymorphism. RESULTS: These data showed the dominance of the gB1 genotype in HCMV-infected infants. The distributions of HCMV gB genotypes in jaundice, malformation, and pneumonia patients are different. CONCLUSION: There are some relationships between the gB genotypes and the different symptoms of HCMV infection. The four gB genotypes of HCMV may have different clinical outcomes in infected infants.
Hong Jin; Xiuxia Wang; Shuomin Li
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Publication Detail:
Type:  Journal Article     Date:  2007-03-14
Journal Detail:
Title:  Intervirology     Volume:  50     ISSN:  0300-5526     ISO Abbreviation:  Intervirology     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-13     Completed Date:  2007-10-16     Revised Date:  2008-08-26    
Medline Journal Info:
Nlm Unique ID:  0364265     Medline TA:  Intervirology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Department of Microbiology and Parasitology, China Medical University, Shenyang, PR China.
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MeSH Terms
Congenital Abnormalities / virology
Cytomegalovirus / genetics*,  isolation & purification,  pathogenicity*
Cytomegalovirus Infections / pathology,  physiopathology*,  virology*
DNA Fingerprinting
DNA, Viral / genetics,  isolation & purification
Infant, Newborn
Jaundice / virology
Pneumonia / virology
Polymerase Chain Reaction / methods
Polymorphism, Restriction Fragment Length
Urine / virology
Viral Envelope Proteins / genetics*
Reg. No./Substance:
0/DNA, Viral; 0/Viral Envelope Proteins; 0/glycoprotein B, Simplexvirus

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