| Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery. | |
| | |
MedLine Citation:
|
PMID: 17574925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cytomegalovirus (CMV)-specific immunity was investigated in human immunodeficiency virus (HIV)-infected individuals. A case-control (1:2) study was performed with cases defined as having a history of CMV end-organ disease (n=15) and controls (n=30) matched by current CD4(+) T cell count. CMV-specific CD8(+) T cells responses were quantified using the high throughput Quantiferon-CMV test (Cellestis, Melbourne, Australia). 40/44 (91%) had a positive Quantiferon-CMV test and the magnitude of response to CMV peptides correlated significantly with response to mitogen (p<0.0001) but not with CD4(+) T cell count at the time of testing, CD4(+) T cell nadir or HIV viral load. Cases had a significantly lower Quantiferon-CMV test than controls but there was no significant difference in response to mitogen or other antigens. In individuals with a history of CMV disease, CMV-specific CD8(+) T cell responses are reduced even in the setting of CD4(+) T cell reconstitution. |
| | |
Authors:
|
K P Singh; J L Howard; S P Wild; S L Jones; J Hoy; S R Lewin |
Related Documents
:
|
21757605 - Improved flagging rates on the sysmex xe-5000 compared with the xe-2100 reduce the numb... 11418475 - Cd8 t cells specific for human immunodeficiency virus, epstein-barr virus, and cytomega... 11472405 - High frequency of circulating hbcag-specific cd8 t cells in hepatitis b infection: a fl... 19494085 - Development of an artificial-antigen-presenting-cell-based assay for the detection of l... 12519785 - Lowered temperature set point for activation of the cellular stress response in t-lymph... 16520945 - Class-, gene-, and group-specific hla silencing by lentiviral shrna delivery. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-15 |
Journal Detail:
|
Title: Clinical immunology (Orlando, Fla.) Volume: 124 ISSN: 1521-6616 ISO Abbreviation: Clin. Immunol. Publication Date: 2007 Aug |
Date Detail:
|
Created Date: 2007-07-20 Completed Date: 2007-09-18 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 200-6 Citation Subset: IM |
Affiliation:
|
Infectious Diseases Unit, Alfred Hospital, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult CD4-Positive T-Lymphocytes / immunology* CD8-Positive T-Lymphocytes / immunology* Case-Control Studies Cytomegalovirus / immunology Cytomegalovirus Infections / complications, immunology*, virology Female HIV / immunology* HIV Infections / complications, immunology*, virology Humans Interferon-gamma / biosynthesis, immunology Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of harvest product volume in erythrocyte depletion of allogeneic or autologous bone marrow us...
Next Document: Second-generation treatment: microwave.