Document Detail


Human correlates of provocative questions in pancreatic pathology.
MedLine Citation:
PMID:  23060061     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies of cell lines and of animal models of pancreatic cancer have raised a number of provocative questions about the nature and origins of human pancreatic cancer and have provided several leads into exciting new approaches for the treatment of this deadly cancer. In addition, clinicians with little or no contact with human pathology have challenged the way that pancreatic pathology is practiced, suggesting that "genetic signals" may be more accurate than today's multimodal approach to diagnoses. In this review, we consider 8 provocative issues in pancreas pathology, with an emphasis on "the evidence derived from man."
Authors:
Oliver G McDonald; Anirban Maitra; Ralph H Hruban
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Advances in anatomic pathology     Volume:  19     ISSN:  1533-4031     ISO Abbreviation:  Adv Anat Pathol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-12     Completed Date:  2013-03-21     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9435676     Medline TA:  Adv Anat Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-62     Citation Subset:  IM    
Affiliation:
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy,  genetics,  pathology*
Animals
Cell Line
Disease Models, Animal
Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Evidence-Based Medicine
Gene Expression Regulation, Neoplastic
Humans
Mice
Neoplasm Invasiveness
Pancreas / pathology*
Pancreatic Neoplasms / drug therapy,  genetics,  pathology*
Grant Support
ID/Acronym/Agency:
P50 CA062924/CA/NCI NIH HHS; P50CA062924/CA/NCI NIH HHS; T32 CA067751/CA/NCI NIH HHS
Comments/Corrections

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