Document Detail

Human coronary collateral recruitment is facilitated by isometric exercise during acute coronary occlusion.
MedLine Citation:
PMID:  22729798     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether isometric exercise increases collateral flow in remote ischaemic myocardium in acute coronary occlusion models of patients with coronary artery disease.
DESIGN: A randomized controlled study.
SUBJECTS: Sixty-five patients with 1-vessel coronary artery disease.
METHODS: Subjects were randomly assigned to either the isometric exercise group or non-exercise group. Patients in the exercise group performed isometric handgrip exercises (50% maximal voluntary contraction) during 1 min coronary balloon occlusion, while patients in the non-exercise group remained sedentary. The collateral flow index, heart rate, systolic blood pressure and diastolic blood pressure were determined prior to and following 1 min of coronary occlusion.
RESULTS: In the exercise group, difference values for collateral flow index (after coronary occlusion before coronary occlusion) were significantly higher than those in the non-exercise group (0.04 standard deviation (SD) 0.05 vs 0.01 (SD 0.03), p < 0.01). Differences in heart rate, systolic blood pressure and diastolic blood pressure were also significantly higher than controls (heart rate 7.84 (SD 8.20) vs 0.88 (SD 3.96), p < 0.01; systolic blood pressure: 3.25 (SD 7.17) vs 1.88 (SD 6.21), p < 0.01; diastolic blood pressure 5.88 (SD 6.40) vs 1.5 (SD 6.22), p < 0.01).
CONCLUSION: Isometric exercise in patients with coronary artery disease induced an increase in coronary collateral flow during acute vessel occlusion, which was significantly different from control occlusion.
Song Lin; Xiao Lu; Shaoliang Chen; Fei Ye; Junjie Zhang; Yulin Ma; Jianan Li
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of rehabilitation medicine     Volume:  44     ISSN:  1651-2081     ISO Abbreviation:  J Rehabil Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2013-05-15     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  101088169     Medline TA:  J Rehabil Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  691-5     Citation Subset:  IM    
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MeSH Terms
Balloon Occlusion
Cohort Studies
Collateral Circulation / physiology*
Coronary Artery Disease / complications,  physiopathology*,  rehabilitation
Coronary Circulation / physiology*
Coronary Occlusion / etiology,  physiopathology*,  prevention & control
Exercise / physiology*
Hand Strength
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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