Document Detail


Human corneal stromal tissue concentration after consecutive doses of topically applied 3.3% vancomycin.
MedLine Citation:
PMID:  14693765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To evaluate vancomycin penetration into human corneal stromal tissue in patients treated with topical vancomycin eyedrops before penetrating keratoplasty (PKP).
METHODS: Twenty four patients who underwent PKP, seven patients with keratoconus (group 1) and 17 patients with corneal scar or corneal decompensation (group 2). All patients received topical application of vancomycin eyedrops (concentration: 33 mg/ml) 10, 3, 2, 1 hour, and 15 minutes before the operation. Corneal cumulative vancomycin levels were assessed by bioassay.
RESULTS: Mean vancomycin corneal stromal tissue concentration was 46.7 (SE 4.11) microg/g tissue. This value was four to 20-fold in excess of the MIC90 of vancomycin in Staphylococcus aureus (2-10 microg/ml).
CONCLUSIONS: Vancomycin reached high corneal tissue concentrations that significantly exceeded the MIC90 (2-10 microg/ml) for most key Gram positive corneal pathogens. The ratio of vancomycin stromal concentration to protein concentration was statistically higher in group 2 (non-keratoconus).
Authors:
M Cahane; G J Ben Simon; I S Barequet; A Grinbaum; L Diamanstein-Weiss; O Goller; E Rubinstein; I Avni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  88     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-24     Completed Date:  2004-02-05     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  22-4     Citation Subset:  IM    
Affiliation:
Goldschleger Eye Institute, Sheba Medical Center, Ramat Gan, 52621 Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Bacterial Agents / administration & dosage,  pharmacokinetics*
Antibiotic Prophylaxis*
Corneal Stroma / metabolism*
Eye Infections, Bacterial / prevention & control
Female
Gram-Positive Bacterial Infections / prevention & control
Humans
Keratitis / prevention & control
Keratoplasty, Penetrating*
Male
Middle Aged
Ophthalmic Solutions
Surgical Wound Infection / prevention & control
Vancomycin / administration & dosage,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Ophthalmic Solutions; 1404-90-6/Vancomycin
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