| Human copper homeostasis: a network of interconnected pathways. | |
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MedLine Citation:
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PMID: 20117961 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Copper plays an essential role in normal human physiology. Copper misbalance affects heart development, CNS and liver function, influences lipid metabolism, inflammation, and resistance to chemotherapeutic drugs. Recent studies yielded new information on the structure, function, and regulation of human copper transporters, uncovered unanticipated functions for copper chaperones, and established connections between copper homeostasis and other metabolic pathways. It has become apparent that the copper trafficking machinery is regulated at several levels and that the cross-talk between cell compartments contributes to the intracellular copper balance. The human copper regulon is emerging. |
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Authors:
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Svetlana Lutsenko |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-02-01 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 14 ISSN: 1879-0402 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 211-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Physiology, Johns Hopkins University, Baltimore, MD 21205, USA. lutsenko@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Cation Transport Proteins / chemistry, metabolism* Copper / metabolism* Humans Ion Transport Models, Molecular Molecular Sequence Data Sequence Alignment |
| Grant Support | |
ID/Acronym/Agency:
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P01 GM067166/GM/NIGMS NIH HHS; R01 DK071865/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cation Transport Proteins; 7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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