Document Detail


Human cone pigment expressed in transgenic mice yields altered vision.
MedLine Citation:
PMID:  10191338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetically driven alterations in the complement of retinal photopigments are fundamental steps in the evolution of vision. We sought to determine how a newly added photopigment might impact vision by studying a transgenic mouse that expresses a human cone photopigment. Electroretinogram (ERG) measurements indicate that the added pigment works well, significantly changing spectral sensitivity without deleteriously affecting the operation of the native cone pigments. Visual capacities of the transgenic mice were established in behavioral tests. The new pigment was found to provide a significant expansion of the spectral range over which mice can perceive light, thus underlining the immediate utility of acquiring a new photopigment. The transgenic mouse also has the receptor basis for a novel color vision capacity, but tests show that potential was not realized. This failure likely reflects limitations in the organizational arrangement of the mouse retina.
Authors:
G H Jacobs; J C Fenwick; J B Calderone; S S Deeb
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  19     ISSN:  0270-6474     ISO Abbreviation:  J. Neurosci.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-04-27     Completed Date:  1999-04-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3258-65     Citation Subset:  IM    
Affiliation:
Neuroscience Research Institute and Department of Psychology, University of California, Santa Barbara, California 93106, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Discrimination (Psychology) / physiology
Electroretinography
Humans
Male
Mice
Mice, Transgenic
Retinal Cone Photoreceptor Cells / metabolism*
Retinal Pigments / biosynthesis*
Ultraviolet Rays
Vision, Ocular / physiology*
Grant Support
ID/Acronym/Agency:
EY02052/EY/NEI NIH HHS; EY08395/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Retinal Pigments

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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